What is the recommended procedure for performing pericardial centesis?

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Last updated: December 21, 2025View editorial policy

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Pericardiocentesis Procedure

Pericardiocentesis must be performed with either echocardiographic or fluoroscopic guidance by an experienced operator in a facility equipped for radiographic, echocardiographic, hemodynamic, and ECG monitoring under local anesthesia. 1

Critical Pre-Procedure Requirements

  • Never perform blind pericardiocentesis except in immediately life-threatening situations where imaging is unavailable 1
  • Ensure experienced operator and staff are available 1
  • Verify facility has complete monitoring capabilities (radiographic, echocardiographic, hemodynamic, ECG) 1
  • Confirm no absolute contraindications exist, particularly aortic dissection 1

Relative Contraindications to Address

  • Uncorrected coagulopathy 1
  • Active anticoagulant therapy 1
  • Thrombocytopenia <50,000/mm³ 1
  • Small (<10 mm), posterior, or loculated effusions (consider surgical approach instead) 1

Echocardiography-Guided Technique (Preferred for Bedside)

Echo guidance is technically less demanding, can be performed at bedside, and has high feasibility (93%) with major complication rates of 1.3-1.6%. 1

Entry Site Selection

  • Identify the point where effusion is closest to the transducer and fluid collection is maximal 1
  • Most commonly: 6th or 7th intercostal space in anterior axillary line 1
  • Mark the intended entry point on skin and carefully note the ultrasound beam direction 1

Structures to Avoid

  • Liver 1
  • Myocardium 1
  • Lung 1
  • Internal mammary artery (stay 3-5 cm away from parasternal border) 1
  • Vascular bundle at inferior margin of each rib 1

Needle Trajectory

  • Define trajectory by angulation of handheld transducer 1
  • Advance needle while continuously visualizing on ultrasound 1

Fluoroscopy-Guided Technique (Catheterization Laboratory)

Fluoroscopic guidance with hemodynamic monitoring allows simultaneous right-heart catheterization to exclude constriction and provides improved feasibility (93.1% vs 73.3% without imaging). 1

Subxiphoid Approach (Most Common)

  • Use Tuohy-17 blunt-tip introducer needle or thin-walled 18-gauge needle with mandrel 1
  • Direct needle toward left shoulder at 30-degree angle to skin 1
  • This route is extrapleural and avoids coronary, pericardial, and internal mammary arteries 1

Fluoroscopic Technique Details

  • Use lateral angiographic view for best visualization of needle position relative to diaphragm and pericardium 1
  • Advance needle slowly toward heart shadow and epicardial halo phenomenon 1
  • Apply moderate suction while advancing 1
  • Inject small amounts of diluted contrast medium intermittently 1

Confirming Needle Position

  • If haemorrhagic fluid aspirates freely, inject a few milliliters of contrast under fluoroscopy 1
  • Sluggish layering inferiorly confirms correct pericardial position 1

Catheter Placement

  • Introduce soft J-tip guidewire through needle 1
  • Check guidewire position in at least two angiographic projections before proceeding 1
  • Dilate tract 1
  • Exchange for multihole pigtail catheter 1
  • Evacuate fluid under control of intrapericardial pressure monitoring 1

Fluid Drainage Strategy

  • Drain fluid in <1 liter steps to avoid acute right ventricular dilatation 1
  • Continue prolonged drainage until intermittent aspiration (every 4-6 hours) yields <25 ml per day 1, 2

Complications and Rates

Overall complication risk ranges from 4-10% depending on monitoring type, operator skill, and clinical setting (emergency vs elective). 1

Major Complications

  • Cardiac chamber or coronary artery laceration/perforation (0.9% with fluoroscopy) 1
  • Arterial bleeding (1.1%) 1
  • Pneumothorax (0.6%) 1
  • Haemothorax 1
  • Hepatic injury 1

Minor Complications

  • Arrhythmias, typically vasovagal bradycardia (0.6% serious arrhythmias) 1
  • Vasovagal reactions (0.3% major) 1
  • Air embolism 1
  • Puncture of peritoneal cavity or abdominal viscera 1
  • Infection (0.3%) 1

Rare Complications

  • Internal mammary artery fistulas 1
  • Acute pulmonary edema 1
  • Purulent pericarditis 1

Special Situations Requiring Surgical Approach

  • Traumatic haemopericardium 1
  • Purulent pericarditis 1, 2, 3
  • Loculated effusions in lateral or posterior position 1
  • Effusions <10 mm 1

Key Safety Measures

  • Direct ECG monitoring from puncturing needle is not an adequate safeguard 1
  • Tangential approach using epicardial halo phenomenon in lateral view significantly increases feasibility in small effusions (89.3% vs 76.7% for <200 ml) 1
  • Echocardiographic guidance achieves 96% feasibility even in loculated effusions 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Pericardiocentesis in Symptomatic Pericardial Effusion with Diastolic Right Heart Failure

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Management of Circumferential Pericardial Effusion

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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