In a trauma patient with an unremarkable Extended Focused Assessment with Sonography for Trauma (E-FAST), which organ is most likely injured: spleen, pancreas, urinary bladder, or liver?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: December 21, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Pancreas (B) is the Most Likely Injured Organ

In a trauma patient with an unremarkable E-FAST, pancreatic injury is the most likely among the options provided because E-FAST has poor sensitivity for detecting pancreatic injuries, which are routinely missed by this modality. 1

Why E-FAST Misses Pancreatic Injuries

  • E-FAST is effective for detecting free fluid and solid organ injuries like spleen and liver (sensitivity 96-100% for these organs when significant free fluid is present), but it is not recommended to routinely diagnose pancreatic trauma. 2

  • Pancreatic injuries are frequently missed by FAST/E-FAST because they often do not produce immediate free fluid, and the retroperitoneal location of the pancreas makes visualization difficult. 1, 3

  • The sensitivity of E-FAST for pancreatic injuries is only 68-91%, with the modality routinely missing bowel and pancreatic injuries compared to its high sensitivity for liver and spleen injuries. 1

Why Other Options Are Less Likely

Spleen and Liver (A and D)

  • Both spleen and liver injuries typically present with free intraperitoneal fluid that E-FAST readily detects. 2

  • E-FAST has high sensitivity (approaching 96-100%) for detecting significant liver and spleen injuries when they produce hemoperitoneum. 2

  • If E-FAST is unremarkable, significant spleen or liver injury is unlikely because these highly vascular organs bleed into the peritoneal cavity, which E-FAST detects effectively. 2

Urinary Bladder (C)

  • Bladder injuries typically present with pelvic free fluid or extraperitoneal fluid collections that can be detected on E-FAST pelvic views. 1

  • The bladder is anatomically located in the pelvis, not the upper abdomen, making it inconsistent with typical blunt abdominal trauma mechanisms that would be missed by E-FAST. 1

Critical Next Steps When E-FAST Is Unremarkable

  • CT scan with intravenous contrast is essential for diagnosing pancreatic injuries in hemodynamically stable patients (sensitivity 97%, specificity 95%). 2, 4

  • Serial measurement of serum amylase and lipase starting 3-6 hours after injury is crucial because pancreatic injury findings are time-dependent and may not be evident immediately. 2, 4

  • Elevated or rising enzyme levels mandate further investigation with CT scan, even if initial imaging is negative. 2, 4

  • Repeat CT scan within 12-24 hours should be considered in patients with high clinical suspicion for pancreatic injury despite negative initial imaging. 2

Common Pitfalls to Avoid

  • Never rely on E-FAST alone to exclude significant intra-abdominal injury when mechanism suggests solid organ injury or when clinical suspicion remains high. 1

  • Do not assume a negative E-FAST rules out pancreatic injury – the American College of Emergency Physicians emphasizes that negative or inconclusive FAST should never be the sole diagnostic test. 1

  • Pancreatic injuries are often overlooked in multiorgan trauma because alterations may not be visualized for several hours following trauma. 3

  • Delayed diagnosis of pancreatic injuries is associated with high morbidity and mortality, making early recognition of main pancreatic duct disruption critical. 3, 5

References

Guideline

Diagnosis and Management of Pancreatic Injury in Handlebar Trauma

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Pancreatic trauma: a concise review.

World journal of gastroenterology, 2013

Guideline

Approach to Suspected Acute Pancreatitis with Atypical Enzyme Pattern

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.