From the Guidelines
A comprehensive treatment plan for osteoarthritis (OA) should include a combination of educational, behavioral, psychosocial, and physical interventions, as well as topical, oral, and intraarticular medications, with the goal of managing symptoms and improving quality of life. When developing a treatment plan, it is essential to consider the patient's personal beliefs and preferences, medical status, and potential comorbidities, such as hypertension, cardiovascular disease, and chronic kidney disease 1. The plan should also take into account the patient's access to services, including transportation, distance, ability to take time off work, cost, and insurance coverage.
Some key considerations in developing a treatment plan for OA include:
- Assessing the patient's medical status and potential comorbidities to determine the best course of treatment
- Considering the patient's personal beliefs and preferences when selecting treatment options
- Starting with treatments that have the least systemic exposure or toxicity
- Addressing potential comorbidities, such as mood disorders, sleep disturbances, and impaired coping skills
- Developing a multimodal treatment plan that incorporates a range of interventions, including medication, lifestyle modifications, and physical therapy
According to the 2019 American College of Rheumatology/Athritis Foundation guideline for the management of OA, treatment decisions should be based on the strength of the recommendation, with a focus on minimizing harm and maximizing benefit 1. The guideline also emphasizes the importance of patient-centered care, with treatment plans tailored to the individual patient's needs and preferences. By taking a comprehensive and patient-centered approach to treatment, healthcare providers can help patients with OA manage their symptoms and improve their quality of life.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Treatment Plan
The treatment plan for hypertension involves the use of angiotensin-converting enzyme (ACE) inhibitors, such as lisinopril, as a first-line therapy 2, 3, 4. The goal of treatment is to lower total peripheral resistance, spare cardiac output, and maintain or improve blood flow to target organs.
Medication Options
- Lisinopril is a suitable treatment for essential hypertension and has been shown to be effective in lowering blood pressure in patients with mild to moderate hypertension 2, 3, 5.
- The medication can be used as a single daily dose, with a long duration of action, making it a convenient option for patients 2, 3.
- Lisinopril has been compared to other antihypertensive medications, such as hydrochlorothiazide, atenolol, and metoprolol, and has been found to be at least as effective in reducing diastolic blood pressure 2, 3, 5.
Combination Therapy
- In some cases, combination therapy with lisinopril and hydrochlorothiazide may be necessary to achieve adequate blood pressure control 5.
- The addition of hydrochlorothiazide to lisinopril has been shown to produce greater blood pressure reductions than either medication alone 5.