Differential Diagnosis for Globus Sensation
Single most likely diagnosis
- Gastroesophageal Reflux Disease (GERD): This is the most common cause of globus sensation, which is often accompanied by symptoms like heartburn and regurgitation. The chronic reflux of stomach acid into the esophagus can irritate the throat, leading to a sensation of a lump.
Other Likely diagnoses
- Anxiety or Stress: Globus sensation can be a symptom of anxiety or stress, as these conditions can cause muscle tension in the throat, leading to the sensation of a lump.
- Dry Mouth (Xerostomia): Reduced saliva production can cause irritation and discomfort in the throat, leading to a globus sensation.
- Postnasal Drip: Excess mucus from the nose can drip down the back of the throat, causing irritation and a sensation of a lump.
- Hypothyroidism: Some patients with hypothyroidism may experience globus sensation due to the metabolic effects of the condition on the muscles and tissues of the throat.
Do Not Miss (ddxs that may not be likely, but would be deadly if missed)
- Esophageal Cancer: Although rare, esophageal cancer can present with globus sensation, among other symptoms like difficulty swallowing and weight loss. Early detection is crucial for treatment.
- Thyroid Cancer: Similar to esophageal cancer, thyroid cancer can cause globus sensation, especially if a nodule or mass is pressing on the esophagus or surrounding structures.
- Angioedema: A severe, potentially life-threatening condition characterized by rapid swelling of the dermis, subcutaneous tissue, mucosa, and submucosal tissues. It can cause a sensation of a lump in the throat.
Rare diagnoses
- Eosinophilic Esophagitis: A chronic inflammatory condition of the esophagus that can cause symptoms similar to GERD, including globus sensation.
- Zenker's Diverticulum: A rare condition where a pouch forms in the pharynx, which can cause difficulty swallowing, regurgitation of food, and a sensation of a lump in the throat.
- Cricopharyngeal Spasm: A condition characterized by spasms of the cricopharyngeus muscle, which can cause globus sensation and difficulty swallowing.