What causes cuboid bone pain?

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Last updated: April 8, 2025View editorial policy

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Differential Diagnosis for Cuboid Pain

  • Single most likely diagnosis
    • Cuboid syndrome: This is a condition where the cuboid bone, one of the bones in the midfoot, becomes misaligned or partially dislocates, leading to pain and discomfort. It is a common cause of lateral foot pain and is often associated with activities that involve repetitive stress on the foot.
  • Other Likely diagnoses
    • Peroneal tendonitis: Inflammation of the peroneal tendons, which run along the lateral side of the foot and ankle, can cause pain in the cuboid area.
    • Lateral plantar fasciitis: Irritation of the plantar fascia on the lateral side of the foot can radiate pain to the cuboid region.
    • Midfoot sprain: A sprain to the ligaments in the midfoot, including those surrounding the cuboid bone, can cause pain and instability.
  • Do Not Miss diagnoses
    • Stress fracture: A fracture of the cuboid bone or other bones in the midfoot can cause severe pain and requires prompt medical attention to prevent further complications.
    • Infection (osteomyelitis or septic arthritis): Infection of the bone or joint in the foot can cause severe pain, redness, and swelling, and requires urgent medical attention.
    • Tumor: Although rare, a tumor in the cuboid bone or surrounding tissues can cause persistent pain and should not be missed.
  • Rare diagnoses
    • Kohler's disease: A rare condition characterized by avascular necrosis of the navicular bone, which can cause midfoot pain, including in the cuboid area.
    • Charcot foot: A condition that occurs in people with diabetes or other conditions that affect nerve function, leading to destruction of the joints and bones in the foot, including the cuboid bone.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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