From the Guidelines
Bergamot supplements may be considered as an adjunct therapy to help lower cholesterol levels, but their long-term safety and efficacy are still uncertain and require further research. When considering the use of bergamot supplements for cholesterol management, it is essential to weigh the potential benefits against the lack of comprehensive data on their long-term effects 1. Some studies suggest that bergamot, along with other nutraceuticals like red yeast rice, berberine, and plant sterols, may have lipid-lowering effects, potentially reducing cardiovascular risk 1. However, the current evidence is not sufficient to draw firm conclusions about their safety and efficacy for long-term use. Key points to consider include:
- Bergamot may inhibit HMG-CoA reductase and limit cholesterol absorption, similar to statins.
- Potential interactions with statins and other cholesterol-lowering medications necessitate caution and consultation with a healthcare provider.
- Side effects are typically mild but may include digestive discomfort.
- Bergamot should complement, not replace, lifestyle modifications like a healthy diet and regular exercise for managing cholesterol. Given the uncertainty surrounding bergamot supplements, it is crucial to prioritize lifestyle modifications and evidence-based pharmacotherapies for cholesterol management, using bergamot only under the guidance of a healthcare provider and with careful monitoring.
From the Research
Bergamot Supplement and Cholesterol
- Bergamot supplements have been shown to reduce total cholesterol and low-density lipoprotein (LDL) cholesterol in patients with hypercholesterolemia 2, 3, 4.
- The mechanism of action of bergamot in reducing cholesterol levels is thought to be related to its polyphenolic compounds, which may inhibit cholesterol synthesis and absorption 5.
- Studies have consistently shown that bergamot supplements are well tolerated and can be used as an alternative therapeutic option for managing dyslipidemia, especially in subjects with statin intolerance 2, 6, 3.
Effects on Lipid Profile
- Bergamot supplements have been shown to decrease total cholesterol, triglycerides, and LDL cholesterol, while increasing high-density lipoprotein (HDL) cholesterol 3, 4.
- The decrease in total cholesterol and LDL cholesterol has been reported to range from 12.3% to 31.3% and 7.6% to 40.8%, respectively 3.
- Bergamot supplements have also been shown to reduce atherogenic small dense LDL particles and subclinical atherosclerosis 4.
Clinical Applications
- Bergamot supplements may be used as a complementary therapy for managing dyslipidemia and related risk factors, especially in patients with mild to moderate hyperlipidemia or those who are intolerant to statins 6.
- The use of bergamot supplements in combination with statins may have a synergistic effect in reducing cholesterol levels 3.