From the Guidelines
An activated Absent In Melanoma 2 (AIM2) inflammasome can affect diseases such as Still's disease and macrophage activation syndrome (MAS).
Diseases Affected by AIM2 Inflammasome
- Still's disease: characterized by elevated levels of serum IL-18 and S100 proteins, which are produced by inflammasome activation 1
- Macrophage activation syndrome (MAS): a condition that can be diagnosed using biomarkers such as IL-18, CXCL-9, and adenosine deaminase 2 (ADA2) activity 1
Mechanism of AIM2 Inflammasome
The AIM2 inflammasome is a multiprotein platform that involves the adaptor protein ASC and NOD-like receptors (NLRs) or the cytosolic DNA sensor AIM2, leading to the activation of caspase-1 and the release of pyrogenic interleukin-1β (IL-1β) and IL-18 1
Clinical Implications
The activation of the AIM2 inflammasome can lead to the production of proinflammatory cytokines, which can drive inflammation and tissue damage in diseases such as Still's disease and MAS 1
From the Research
Diseases Affected by Activated AIM2 Inflammasome
The activation of the Absent In Melanoma 2 (AIM2) inflammasome has been implicated in various diseases, including:
- Autoimmune diseases:
- Cancers:
- Oral diseases:
- Various oral diseases, with the AIM2 inflammasome potentially being a key link between oral diseases and innate immunity 4
- Inflammatory diseases:
- Metabolic diseases:
- Liver diseases: