Diabetic Foot Ulcer Healing Time with Regen-D Ointment
Regen-D ointment (recombinant human epidermal growth factor) achieves complete healing of diabetic foot ulcers in an average of 4.8 weeks in real-world clinical practice, with over 90% of patients healed by 10 weeks. 1
Evidence for Regen-D Healing Times
The most robust data comes from post-marketing surveillance of Regen-D 150 in 135 diabetic foot ulcer patients, which demonstrated:
- Average healing time: 4.8 weeks 1
- Healing rate at 10 weeks: >90% of patients 1
- Overall cure rate: 86% 1
These real-world results substantially outperformed the Phase III clinical trial data for the same product, where average healing time was 9 weeks and only 69% of patients were healed by week 10 (compared to 18% with placebo). 1
Mechanism and Clinical Benefits
Regen-D 150 works by:
- Stimulating healthy granulation tissue formation 1
- Accelerating epithelialization 1
- Significantly reducing healing duration compared to standard care 1
- Providing excellent quality wound healing and reepithelization 1
Context: Standard Care Healing Times
To appreciate Regen-D's efficacy, standard care healing times vary dramatically by ulcer etiology:
- Neuropathic ulcers: Average 77.7 days (11 weeks) with standard care 2
- Neuroischemic ulcers: Average 123.4 days (17.6 weeks) 2
- Ischemic ulcers: Average 133 days (19 weeks), with 3 of 8 patients failing to heal 2
Ulcer size also impacts healing time: Larger ulcers (>200 mm²) require approximately 97 days versus 70 days for smaller ulcers (<100 mm²) under standard care. 3
Clinical Decision Point
Monitor healing progress at 4 weeks: A reduction in ulcer area of >53% at 4 weeks predicts 58% likelihood of complete healing by 12 weeks, whereas <53% reduction predicts only 9% healing rate. 4 This serves as a critical decision point to intensify treatment if inadequate response occurs. 4
Important Caveats
- Only 30-40% of diabetic foot ulcers heal at 12 weeks with standard care alone 5
- Recurrence rates are high: 42% at 1 year and 65% at 5 years after healing 5
- The 4.8-week average healing time with Regen-D represents optimal conditions; individual results depend on ulcer etiology, size, infection status, and vascular supply 2, 3