Which nerve root is affected by loss of sensation in the left calf and lateral aspect of the left foot?

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Nerve Root Affected: L5-S1 (Option C)

The patient's presentation of sensory loss in the left calf and lateral aspect of the left foot indicates L5-S1 nerve root involvement, specifically affecting the L5 nerve root. 1

Neuroanatomical Correlation

The L5-S1 disc lesion typically compresses the L5 nerve root as it exits the neural foramen, producing characteristic sensory deficits in specific distributions 1:

  • L5 nerve root compression causes sensory loss in the dorsal aspect of the foot, including the big toe 1
  • The lateral aspect of the foot and calf falls within the L5 dermatome distribution 1
  • This differs from S1 nerve root compression, which produces lateral foot and plantar flexion deficits 2

Why Other Options Are Incorrect

L1-L2 (Option A): This nerve root level affects the lateral thigh region, not the calf or foot 2

L3-L4 (Option B):

  • L4 nerve root affects the medial lower leg and medial thigh, not the lateral calf or lateral foot 3, 2
  • L4 radiculopathy typically presents with diminished patellar reflex and medial leg sensory changes 3

S1-S2 (Option D):

  • S1 nerve root primarily affects plantar flexion strength and the Achilles reflex 2
  • While S1 can affect the lateral foot, it does not typically cause calf sensory loss in the distribution described 1

Clinical Confirmation

To confirm L5 nerve root involvement, assess for:

  • Motor deficits: Foot dorsiflexion weakness and great toe extension weakness (L5-mediated movements) 1
  • Reflex changes: Ankle jerk reflex may be affected rather than knee jerk reflex 1
  • Sensory pattern: Dorsal foot and big toe sensory loss is the hallmark finding 1

Diagnostic Approach

  • MRI is the imaging modality of choice for visualizing lumbosacral nerve root pathology and L5-S1 disc lesions 1
  • Electrodiagnostic studies should be considered to differentiate radiculopathy from plexopathy 1
  • The most common site for symptomatic lumbar disc herniation is L4/L5 and L5/S1 levels 3

References

Guideline

L5-S1 Disc Lesion Neurological Effects

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Lateral Thigh Sensation and Nerve Root Pathology

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

L4 Lumbar Radiculopathy Diagnosis and Exclusion Criteria

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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