Daflon 1000mg Dosing
The standard recommended dose of Daflon for adults is 1000 mg daily, administered as two 500 mg tablets per day. 1
Standard Dosing Regimen
For chronic venous insufficiency and hemorrhoids, the established dose is 1000 mg daily (two 500 mg tablets), taken as a single daily dose or divided into two doses. 1, 2, 3
Each tablet contains 500 mg of micronized purified flavonoid fraction (MPFF), consisting of 90% diosmin and 10% hesperidin. 1, 2
The micronization process enhances absorption of diosmin by reducing particle size to <2 micrometers. 2
Condition-Specific Dosing
Acute Hemorrhoids
For acute internal hemorrhoids (grade 1 or 2), use an intensive regimen: 3 tablets (1500 mg) twice daily for 4 days, then 2 tablets (1000 mg) twice daily for 3 days. 2
This higher-dose regimen significantly improves the duration and intensity of acute hemorrhoidal symptoms compared to placebo. 2
Chronic Hemorrhoids and Chronic Venous Insufficiency
For chronic (recurrent) hemorrhoids and chronic venous insufficiency, the standard maintenance dose is 2 tablets (1000 mg) daily for 60-83 days or longer. 2, 4, 5
This dosing reduces frequency, duration, and severity of symptoms while improving overall disease signs. 2, 6
Venous Leg Ulcers
For venous leg ulcers ≤10 cm in diameter, use 1000 mg daily (two 500 mg tablets) in combination with standard compression therapy and local wound management. 2
Treatment duration typically ranges from 2-6 months, with MPFF significantly accelerating ulcer healing compared to standard management alone. 2, 4
Safety Profile
Daflon demonstrates excellent tolerability with adverse events similar to placebo. 7, 2
The most commonly reported adverse events are mild gastrointestinal disturbances (dyspepsia in up to 7% of patients) and headaches, which rarely lead to treatment discontinuation. 7, 2
No serious adverse events have been reported in clinical trials using doses ranging from 400 to 5000 mg/day for up to one year. 7
Rare adverse events (<2%) include rash, lower limb cramping, phlebitis, and venous thrombosis, occurring at frequencies not significantly different from placebo. 7
No dose adjustments are required for elderly patients (≥70 years) or those with concomitant conditions such as hypertension, diabetes, or atherosclerosis. 7
Administration Considerations
The medication can be taken once daily or divided into two doses, with or without food. 3, 5
Taking doses with meals or at bedtime may minimize gastrointestinal side effects if they occur. 3
The exact dosing regimen of 2 tablets daily (1000 mg total) shows high patient acceptance due to simplicity and excellent tolerability. 3