Ward Management of Desaturation
For any patient with desaturation in a ward setting, immediately administer high-flow oxygen at 15 L/min via reservoir mask if SpO₂ <85%, or 2-6 L/min via nasal cannulae if SpO₂ 85-93%, while simultaneously performing rapid ABCDE assessment to identify and treat the underlying cause. 1
Immediate Oxygen Delivery Based on Severity
Critical Desaturation (SpO₂ <85%)
- Administer the highest possible inspired oxygen concentration using a reservoir mask at 15 L/min immediately, regardless of COPD status or hypercapnic risk, until the situation stabilizes 1
- This applies to all patients, even those with known risk factors for hypercapnia, as life-threatening hypoxemia takes priority 1
Moderate Desaturation (SpO₂ 85-93%)
- Start oxygen at 2-6 L/min via nasal cannulae or 5-10 L/min via simple face mask 1
- Target SpO₂ 94-98% for most acutely ill patients 2, 1
- For patients with known COPD, morbid obesity, cystic fibrosis, chest wall deformities, neuromuscular disorders, or bronchiectasis, target SpO₂ 88-92% instead 2, 1
Mild Desaturation (SpO₂ >93% but below baseline)
- Initiate supplemental oxygen to maintain target range 2
- Document baseline oxygen requirements and adjust accordingly 2
Rapid Clinical Assessment Algorithm
Verify Equipment Function First
- Check pulse oximetry signal quality, proper probe placement, and adequate waveform that correlates with pulse rate 1
- Verify oxygen delivery system connections, as disconnections cause serious incidents 2
- Ensure adequate oxygen supply is available 2
ABCDE Assessment
- Airway: Assess for patency and obstruction; consider simple airway maneuvers or adjuncts if compromised 3
- Breathing: Record respiratory rate (>30 breaths/min requires increased oxygen flow rates), work of breathing, and auscultate for pneumothorax, pulmonary edema, or bronchospasm 2, 1
- Circulation: Check heart rate, blood pressure, and signs of shock or low cardiac output 3
- Disability: Assess level of consciousness and mental status changes 3
- Exposure: Look for contributing factors like fever, trauma, or signs of pulmonary embolism 1
Life-Threatening Causes Requiring Immediate Intervention
- Tension pneumothorax 1
- Massive pulmonary embolism 1
- Acute pulmonary edema 1
- Complete airway obstruction 3
Oxygen Titration and Monitoring
Adjusting Oxygen Delivery
- If saturation falls below target range, increase oxygen concentration; if saturation rises above target range, decrease oxygen concentration 2
- Record new saturation and delivery system/flow rate on observation chart after 5 minutes of treatment at new oxygen concentration 2
- Each change must be documented by clinician trained to administer oxygen 2
When to Obtain Blood Gases
- Patients at risk of hypercapnic respiratory failure (target 88-92%) require repeat blood gas assessment 30-60 minutes after any increase in oxygen therapy to ensure CO₂ is not rising 2
- For patients with no hypercapnic risk and stable clinical status, pulse oximetry monitoring alone is sufficient 2
- If saturation fails to rise following 5-10 minutes of increased oxygen, or if clinical concern exists, repeat blood gases 2
Continuous Monitoring Requirements
- Pulse oximetry to detect early desaturation 3
- Respiratory rate, heart rate, blood pressure, and mental status 3, 1
- Document oxygen saturation and delivery device on respiratory section of observation chart 2
Special Patient Populations
COPD or Risk of Hypercapnic Respiratory Failure
- Use 24% Venturi mask at 2-3 L/min (or 28% Venturi mask at 4 L/min) with target SpO₂ 88-92% pending blood gas results 2
- Never abruptly discontinue oxygen in these patients, as this causes life-threatening rebound hypoxemia with rapid fall below baseline SpO₂ 1
- If pH and PCO₂ are normal on initial blood gases, may increase target to 94-98% unless history of previous hypercapnic failure requiring NIV 2
- Recheck blood gases at 30-60 minutes even if initial PCO₂ was normal 2
Obese Patients
- Position in head-up position (25-30°) to improve functional residual capacity 3, 4
- These patients are at higher risk for rapid desaturation due to reduced functional residual capacity 3
Cardiac Patients
- Do not routinely administer oxygen if SpO₂ ≥94%, as supplemental oxygen in normoxemic acute coronary syndrome patients increases myocardial injury and infarction size 1
- Only give oxygen if SpO₂ <94%, signs of heart failure, shock, or breathlessness present 1
Escalation of Respiratory Support
When Standard Oxygen Fails
- If patient remains hypoxemic despite high-flow oxygen via reservoir mask, consider non-invasive positive pressure ventilation (NIPPV) with CPAP 5-10 cmH₂O 2, 4
- High-flow nasal oxygen (HFNO) at 30-70 L/min is an alternative, though NIPPV has stronger evidence for preventing critical desaturation 2, 4
- Position patient head-up at 35° to reduce airway swelling and improve oxygenation 3
Preparing for Intubation
- If desaturation persists despite maximal non-invasive support, prepare for definitive airway management 3
- Continue preoxygenation with NIPPV or HFNO until ready to intubate 2, 4
- Have backup airway plan ready, limiting intubation attempts to three 3
Critical Pitfalls to Avoid
Oxygen Management Errors
- Never delay oxygen therapy for seriously ill patients to obtain baseline saturation measurements 2
- Do not reduce oxygen too rapidly in patients with hypercapnic risk; step down gradually to lowest level maintaining target saturation 1
- Increasing oxygen flow rate into a Venturi mask does not increase oxygen concentration delivered; it only compensates for high respiratory rates 2
Monitoring Errors
- Pulse oximetry may be inaccurate below 80% saturation 3
- Supplemental oxygen may mask hypoventilation by delaying onset of hypoxemia 3
- Transient desaturations may occur without consequence, but persistent desaturation requires intervention 3
Clinical Assessment Errors
- Endobronchial intubation causes nearly one-fifth of all desaturations under anesthesia; always verify tube position 5
- Failure to position patient head-up is the most common error in managing hypoxemic patients 4
- Do not assume desaturation is benign; half of cases are due to underlying lung disease, secretions, or obesity requiring specific management 5