Can zinc (Zn) supplements be stopped before surgery?

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Last updated: April 9, 2025View editorial policy

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From the Guidelines

It is recommended to stop taking zinc supplements, such as Zin Puches, at least 1-2 weeks before surgery. This is based on the consensus statement from the Society for Perioperative Assessment and Quality Improvement (SPAQI) 1, which suggests that dietary supplements, including zinc, should be held before surgery due to potential risks such as increased bleeding risk and interactions with medications. When considering the management of supplements before surgery, it's essential to weigh the potential benefits against the risks, and in the case of zinc supplements, the risks may outweigh the benefits 1. Some key points to consider include:

  • Informing your surgeon about all supplements you're taking during your pre-operative consultation
  • The potential for zinc to interfere with blood clotting and interact with certain medications used during surgery
  • The possibility that zinc supplements may affect how your body responds to anesthesia
  • The distinction between zinc supplements and the small amounts of zinc found in multivitamins or regular dietary intake from foods. Ultimately, the decision to stop taking zinc supplements before surgery should be made in consultation with your healthcare provider, as they can provide personalized advice based on your specific medical needs 1.

From the Research

Stopping Zinc Supplements Before Surgery

  • There is no direct evidence to suggest that stopping zinc supplements before surgery is necessary or beneficial 2, 3, 4, 5, 6.
  • Zinc plays a crucial role in wound healing, and deficiency can lead to delayed healing 2, 4.
  • Topical zinc therapy has been shown to be effective in promoting wound healing, reducing superinfections, and enhancing local defense systems 2.
  • Oral zinc supplementation may be beneficial in treating zinc-deficient patients, but its therapeutic place in surgical patients needs further clarification 2, 3.
  • Parenteral supplementation with zinc in surgical patients can correct postoperative serum-zinc drop and improve clinical wound healing 3.
  • The risks and benefits of zinc supplementation should be carefully considered, as excessive consumption can cause copper deficiency and other adverse effects 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Zinc in wound healing: theoretical, experimental, and clinical aspects.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2007

Research

The role of zinc in wound healing.

Advances in wound care : the journal for prevention and healing, 1999

Research

Zinc requirements and the risks and benefits of zinc supplementation.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2006

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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