What volume does diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)) eye drops come in?

Diclofenac Eye Drop Volume

Diclofenac ophthalmic solution 0.1% (Voltaren Ophtha) is typically supplied in 5 mL bottles for eye drop formulations. 1

Standard Packaging Information

• The ophthalmic formulation of diclofenac sodium 0.1% comes as eye drops in small volume bottles suitable for topical ocular administration 1
• The standard dosing regimen is 1 drop instilled 4 times daily, which makes the 5 mL volume appropriate for a typical treatment course 1

Important Distinction from Other Formulations

• Do not confuse ophthalmic diclofenac with topical gel formulations, which come in much larger volumes (typically 50-100 gram tubes) and are used for dermatologic or musculoskeletal conditions 2
• Diclofenac 3% gel in 2.5% hyaluronic acid for actinic keratosis is applied to skin surfaces, not eyes 2
• Oral diclofenac tablets come in 25-75 mg strengths and are completely different from the eye drop formulation 2

Clinical Context

• The 0.1% ophthalmic concentration is specifically formulated for ocular use and has demonstrated efficacy in treating conditions like filamentary keratitis when dosed as 1 drop four times daily for 28 days 1
• This formulation achieves peak plasma concentrations rapidly but is designed for local ocular effect rather than systemic absorption 1