What are the key characteristics to note when describing a lipoma on physical exam?

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Physical Examination Description of Lipoma

A lipoma on physical exam should be described as a soft, mobile, well-circumscribed subcutaneous mass with a characteristic "doughy" consistency that moves easily under palpation. 1

Essential Physical Characteristics to Document

Texture and Consistency

  • Soft and doughy feel is the hallmark characteristic that distinguishes lipomas from other masses 1
  • The mass should be rubbery and compressible under palpation 2
  • Note whether the lesion demonstrates the "pillow sign" (indentation when pressed with fingers or instruments), which has 98% specificity for lipoma 3

Mobility and Borders

  • Mobile and freely movable beneath the skin, not fixed to underlying structures 1
  • Well-defined, smooth margins that are easily palpable 1, 4
  • The mass should move independently of the overlying skin 2

Size and Shape

  • Document exact measurements in centimeters (length, width, depth if palpable) 5
  • Most lipomas are small (less than a few inches), but note that masses >5 cm require additional evaluation 6, 7
  • Lipomas are typically elongated with their greatest diameter parallel to the skin surface 4

Pain and Tenderness

  • Lipomas are typically painless and non-tender on palpation 1
  • Any tenderness or pain is atypical and warrants further investigation 6, 7

Location

  • Document the anatomic location precisely (most commonly neck, shoulders, back, abdomen, arms, or thighs) 1
  • Note whether the mass is superficial (subcutaneous) or deep-seated, as deep location raises concern for atypical lipomatous tumor 6, 3

Critical Red Flags Requiring Advanced Evaluation

Document and escalate if any of the following are present:

  • Size >5 cm (giant lipoma or possible malignancy) 6, 7, 5
  • Rapid growth or recent change in size 6, 7
  • Pain or tenderness (atypical for benign lipoma) 6, 7
  • Fixed or immobile mass (suggests deeper involvement) 1
  • Firm or hard consistency (inconsistent with lipoma) 1
  • Deep-seated location, especially in lower limb (higher risk of atypical lipomatous tumor) 6

Important Clinical Pitfalls

  • Physical examination alone is only 85% accurate for diagnosing lipomas, so imaging confirmation is important for atypical presentations 3
  • Do not rely solely on clinical impression for masses with any red flag features—these require ultrasound at minimum 6, 3
  • A palpable mass that feels like a lipoma but is painful, growing, or >5 cm mandates imaging (ultrasound first, then MRI if concerning features) 6, 7

References

Research

Lipoma excision.

American family physician, 2002

Guideline

Ultrasound Features of Lipomas

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Giant Lipoma: A Case Report.

Cureus, 2024

Guideline

Diagnostic Imaging for Lipoma

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Diagnostic Approach for Multiple Lipomas

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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