Starting Dose of Uzedy
I cannot provide dosing information for Uzedy based on the evidence provided, as none of the studies or guidelines reference this medication.
Critical Issue with Question
The evidence provided exclusively discusses pegfilgrastim (brand names Neulasta, Fulphila, G-Lasta) and filgrastim products, which are granulocyte colony-stimulating factors used to prevent chemotherapy-induced neutropenia. However, the question asks about "Uzedy," which appears to be a different medication entirely.
The expanded question mentions "Udenyca (pegfilgrastim-cbqv)," which is indeed a pegfilgrastim biosimilar. If this is what you're asking about, the standard dosing would be:
Standard Pegfilgrastim Dosing (If Applicable)
The recommended starting dose for pegfilgrastim products is 6 mg administered as a single subcutaneous injection per chemotherapy cycle 1, 2.
Key Administration Details:
- Timing: Administer 24-72 hours (1-3 days) after completion of chemotherapy 1
- Route: Subcutaneous injection is the preferred route 1
- Frequency: One dose per chemotherapy cycle (not daily dosing) 1
- Critical caveat: Never administer on the same day as chemotherapy, as this increases febrile neutropenia and adverse events 1, 3
Pediatric Dosing Exception:
- For pediatric patients, a weight-based dose of 100 mcg/kg may be used instead of the fixed 6 mg dose 2
- The 6 mg fixed dose should not be used in patients weighing less than 45 kg 1
Clarification Needed
If "Uzedy" refers to a different medication than pegfilgrastim products, please provide the generic name or indication so I can provide accurate dosing information.