Maximum Dose of Restorolax (Polyethylene Glycol) Per Day
There is no clearly defined maximum daily dose for polyethylene glycol (PEG) according to the American Gastroenterological Association and American College of Gastroenterology guidelines, with dosing titrated based on symptom response and side effects rather than a fixed upper limit. 1, 2
Guideline-Based Dosing Approach
The standard approach is to titrate PEG dosing according to individual symptom response and tolerability, without a specified maximum dose ceiling. 1, 2
The American Gastroenterological Association recommends starting with 17 grams daily for chronic idiopathic constipation, with adjustments made based on clinical response. 1
Dosing should be individualized to achieve adequate symptom relief while minimizing side effects such as bloating, abdominal discomfort, and cramping. 2
Evidence from Clinical Studies
While guidelines don't specify a maximum, research provides context on higher-dose safety:
A single dose of 68 grams of PEG 3350 was found safe and effective for rapid relief within 24 hours in constipated adults, with no adverse reactions, electrolyte disturbances, or complaints of cramps or diarrhea. 3
Even at 85 grams as a single dose, no significant safety concerns were identified in adult patients. 3
Long-term use at standard doses (12-24 grams daily) has demonstrated safety in elderly institutionalized patients without clinically significant electrolyte abnormalities. 4
Practical Dosing Recommendations
Begin with 17 grams daily and increase gradually based on response, monitoring for bloating and flatulence which may be limiting at higher doses. 1
Ensure adequate hydration when using PEG, especially at higher doses, to optimize efficacy and minimize side effects. 2
PEG has shown durable response over 6 months for chronic idiopathic constipation, making it suitable for long-term management. 2
Important Caveats
The absence of a defined maximum dose does not mean unlimited dosing is appropriate—clinical judgment based on response and tolerability should guide therapy. 1, 2
PEG is the only osmotic laxative studied in pregnancy, though bloating and flatulence may limit tolerability if preexisting symptoms are present. 1