Treatment of Dry, Scaly Skin Under the Eyes
Apply hydrocortisone 1% cream to the affected periocular skin 3-4 times daily for up to 2 weeks maximum, combined with hypoallergenic moisturizing cream at least once daily and preservative-free artificial tears at least 4 times daily. 1
Initial Treatment Protocol
The periocular skin requires a multi-pronged approach addressing both the skin barrier dysfunction and any associated ocular surface disease:
Topical Skin Management
- Apply hydrocortisone 1% cream to the dry, scaly areas under the eyes 3-4 times daily for a maximum of 2 weeks to reduce inflammation and restore the skin barrier 1
- Use hypoallergenic, preservative-free moisturizing cream to the periocular area at least once daily, with ceramide-containing formulations being particularly effective for restoring the skin's lipid barrier 1
- Limit corticosteroid use strictly to 2 weeks on eyelid skin to avoid complications including skin atrophy, telangiectasia, and systemic absorption 1
Ocular Surface Protection
- Apply preservative-free artificial tears containing methylcellulose or hyaluronate at least 4 times daily, increasing frequency based on symptom severity 1
- Use lubricating ointment at bedtime for overnight protection if any ocular surface symptoms are present 1
Lid Hygiene Protocol
This is essential even when the primary complaint is periocular skin changes, as blepharitis and meibomian gland dysfunction commonly contribute:
- Apply warm compresses to closed eyelids for 5-10 minutes twice daily using specially designed battery-powered or microwaveable eyelid warming devices 1
- Perform gentle eyelid massage after warm compresses to express thickened meibomian gland secretions 1
- Cleanse eyelid margins using diluted baby shampoo or commercial eyelid cleaners on a cotton pad to remove crusting and flaking 1
Environmental Modifications
These interventions address underlying triggers that perpetuate the condition:
- Eliminate exposure to cigarette smoke, which adversely affects the tear film lipid layer 1
- Humidify ambient air and avoid air drafts by using side shields on spectacles 1
- Lower computer screens below eye level to decrease eyelid aperture and reduce evaporative loss 1
- Schedule regular breaks during screen time and increase conscious blinking 1
Escalation for Refractory Cases
If symptoms persist after 2 weeks of initial therapy:
- Switch to tacrolimus 0.1% ointment applied once daily to external eyelids and lid margins for 2-4 weeks, which demonstrates 89% response rates for cases not responding to initial therapy 1
- Add topical antibiotic ointment to lid margins once or twice daily for 2-4 weeks if blepharitis is contributing 1
- Use lipid-containing tear supplements if meibomian gland dysfunction is contributing to symptoms 1
Critical Timing for Referral
- Arrange ophthalmology evaluation within 4 weeks if symptoms persist despite initial treatment 1
- Refer immediately if moderate or severe eye pain, vision loss or blurred vision, corneal infiltration or ulceration, or lack of response to initial therapy after 2-4 weeks develops 1
Common Pitfalls to Avoid
- Never extend topical corticosteroid use beyond 2 weeks on the eyelid skin due to the thin, sensitive nature of periocular tissue 1
- Avoid using preserved artificial tears more than 4 times daily, as overuse causes toxicity to the ocular surface 1
- Do not use tacrolimus ointment in patients with a history of ocular-surface herpes simplex virus or varicella zoster virus 1
- Counsel patients that long-term maintenance therapy may be required, as symptoms often recur when treatment is discontinued 1