What antiemetics will not prolong the QT or QTc interval?

From the Research

Antiemetics and QT Interval Prolongation

• The following antiemetics have been studied for their potential to prolong the QT or QTc interval:
  • Ondansetron: Studies have shown that ondansetron does not significantly prolong the QTc interval 1, 2.
  • Dolasetron: Similar to ondansetron, dolasetron has been found not to lengthen the QT interval 1.
  • Domperidone: However, domperidone has been linked to QT interval prolongation 3, 4.
  • Metopimazine: There is no statistically significant association between metopimazine and QT interval prolongation 4.
  • Granisetron: Granisetron has been associated with a higher risk of cardiac adverse events related to QT interval prolongation 4.

Antiemetics That Do Not Prolong the QT Interval

• Based on the available evidence, the following antiemetics do not appear to prolong the QT or QTc interval:
  • Ondansetron 1, 2
  • Dolasetron 1
  • Metopimazine 4
• It is essential to note that individual patient responses may vary, and other factors can influence the risk of QT interval prolongation.

Studies with Relevant Findings

• A study published in the Mayo Clinic proceedings found that perioperative doses of ondansetron or dolasetron do not lengthen the QT interval 1.
• Another study published in The American journal of emergency medicine found no difference in the change in QTc interval at 4 hours post-study drug administration between a 24-mg bimodal-release ondansetron pill and placebo 2.