What is the significance of a 14-year-old male patient's blood pressure of 100/70, slightly low hemoglobin (Hb) level of 12.6 gm/dl, and elevated eosinophil count of 4%, in the context of his symptoms of giddiness and current medication, pantoprazole?

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Blood Pressure and Laboratory Findings Assessment in a 14-Year-Old Male

Blood Pressure Interpretation

The blood pressure of 100/70 mmHg in this 14-year-old male is normal and does not require intervention. 1

  • For adolescents ≥13 years of age, normal blood pressure is defined as less than 120/80 mmHg 1
  • The 50th percentile (median normal) for 14-year-old boys is approximately 118/73 mmHg 1
  • This patient's reading of 100/70 mmHg falls well below both the normal threshold and the median, indicating no hypertensive concern 1
  • Blood pressure should be measured at every clinic visit using appropriate cuff size with the patient seated and relaxed 2

Hemoglobin Analysis

The hemoglobin of 12.6 gm/dl represents mild anemia that warrants further evaluation, particularly given the patient's symptoms of giddiness.

  • While this Hb level is only slightly below the lower limit of normal for a 14-year-old male (typically ~13-16 gm/dl), it may be clinically significant in the context of his presenting symptom
  • The mean cell volume (MCV) of 80 fL is at the lower end of normal (80-100 fL), suggesting possible microcytic anemia
  • The mean cell hemoglobin (MCH) of 24.3 pg is low (normal 27-31 pg), further supporting microcytic hypochromic anemia
  • The elevated RDW-CV of 15.7% (normal 11.5-14.5%) indicates increased variation in red blood cell size, consistent with iron deficiency anemia or other nutritional deficiencies

The combination of low-normal MCV, low MCH, and elevated RDW strongly suggests iron deficiency anemia as the most likely diagnosis.

Eosinophil Count

The eosinophil count of 4% is within normal limits (1-6%) and does not require specific intervention.

  • This finding is not clinically significant in isolation
  • Normal eosinophil counts do not explain the patient's symptoms

Platelet Count

The platelet count of 151,000/cumm is within normal range (150,000-400,000/cumm) and is not concerning.

  • However, given the patient is on pantoprazole, awareness of rare drug-induced thrombocytopenia is warranted 3
  • Pantoprazole has been reported to cause severe thrombocytopenia (>70% decrease in platelet count) in rare cases, though this patient's count remains normal 3

Clinical Significance of Giddiness

The patient's giddiness is most likely multifactorial, related to the mild anemia rather than blood pressure issues.

  • The blood pressure is normal and not hypotensive enough to cause orthostatic symptoms in a healthy adolescent
  • Mild anemia (Hb 12.6 gm/dl) can cause dizziness, fatigue, and lightheadedness, particularly with exertion
  • Iron deficiency anemia, suggested by the CBC indices, commonly presents with these symptoms

Pantoprazole Considerations

Pantoprazole use should be reviewed for appropriateness and duration, as it may contribute to anemia through impaired iron absorption.

  • Proton pump inhibitors like pantoprazole can impair iron absorption by reducing gastric acid, potentially worsening iron deficiency anemia
  • While pantoprazole is generally safe, rare adverse effects include thrombocytopenia 3, acute interstitial nephritis 4, and hematologic abnormalities
  • The current platelet count is normal, but monitoring is reasonable given the medication exposure 3

Recommended Actions

Immediate steps should include:

  • Iron studies (serum iron, ferritin, total iron-binding capacity, transferrin saturation) to confirm iron deficiency anemia
  • Reticulocyte count to assess bone marrow response
  • Stool occult blood testing if gastrointestinal blood loss is suspected
  • Dietary assessment to identify nutritional deficiencies
  • Review indication for pantoprazole and consider discontinuation if not essential, as it may impair iron absorption
  • Iron supplementation if iron deficiency is confirmed
  • Repeat CBC in 4-6 weeks after initiating iron therapy to assess response

Common Pitfalls to Avoid

  • Do not dismiss mild anemia as insignificant when symptoms are present
  • Do not attribute dizziness to "normal" blood pressure without considering other causes
  • Do not overlook the potential for proton pump inhibitors to contribute to iron malabsorption
  • Do not assume a single blood pressure reading is definitive; however, in this case, the reading is clearly normal and not contributory to symptoms 1

References

Guideline

Blood Pressure Guidelines for Adolescents

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Acute interstitial nephritis due to pantoprazole.

The Annals of pharmacotherapy, 2004

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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