From the FDA Drug Label
DOSAGE AND ADMINISTRATION ... For treatment of pain or primary dysmenorrhea the recommended dosage is 50 mg three times a day ... For the relief of osteoarthritis, the recommended dosage is 100-150 mg/day in divided doses, 50 mg twice a day or three times a day ... For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided doses, 50 mg three times a day or four times a day. The recommended dose of Cambia (diclofenac) is:
- 50 mg three times a day for pain or primary dysmenorrhea
- 100-150 mg/day in divided doses for osteoarthritis
- 150-200 mg/day in divided doses for rheumatoid arthritis 1
From the Research
Cambia (diclofenac potassium) should be prescribed as a single 50 mg packet dissolved in water, taken as needed for acute migraine attacks, with a maximum of one dose per day, as supported by the most recent and highest quality study 2. The powder should be completely dissolved in 1-2 ounces of water before drinking. Do not take more than one dose in a 24-hour period, as exceeding this dose increases the risk of side effects without providing additional benefit. Cambia works by inhibiting prostaglandin synthesis through blocking cyclooxygenase enzymes (COX-1 and COX-2), which helps reduce inflammation and pain associated with migraines. This medication should be taken at the first sign of migraine symptoms for best effectiveness. Some key points to consider when prescribing Cambia include:
- Patients with cardiovascular disease, kidney problems, or a history of gastrointestinal bleeding should use caution with this medication and consult their healthcare provider about appropriate dosing.
- Common side effects may include nausea, stomach discomfort, and dizziness.
- The use of acute treatment should be limited to a maximum of ten days a month to prevent medication-overuse headache, as recommended by the American Headache Society 3.
- Cambia is suitable for mild to moderate migraine attacks and remains a first-line option for acute migraine treatment, as supported by recent clinical trials and meta-analyses 4, 2.
- The combination of a triptan and a NSAID, such as sumatriptan and naproxen, yielded a better efficacy compared with either therapy alone, but the effect was greater for the same dose of either sumatriptan or naproxen alone, and additional benefits over sumatriptan alone were not large 5.
- Nonpharmacologic treatments, such as remote electrical neuromodulation, transcranial magnetic stimulation, external trigeminal nerve stimulation, and noninvasive vagus nerve stimulation, were significantly associated with improved pain, with moderate to low strength of evidence 2.