What are the adverse effects of excessive Cannabis sativa (hemp) seed consumption?

From the Research

Adverse Effects of Excessive Cannabis sativa (Hemp) Seed Consumption

The consumption of Cannabis sativa (hemp) seeds has been associated with several adverse effects, particularly when consumed in excess. Some of the potential adverse effects include:

• Psychoactive effects due to high concentrations of Δ9-tetrahydrocannabinol (Δ9-THC) [ 1 ]
• Fear, distrust, and a profound state of unease, hallucinations, ataxia, stupor, and seizures [ 2 ]
• Respiratory and cardiovascular toxicity, and an increased risk of psychiatric conditions [ 2 ]
• Cannabinoid hyperemesis syndrome, which can occur with chronic use [ 2 ]
• Impaired coordination and performance, anxiety, suicidal ideations/tendencies, and psychotic symptoms [ 3 ]
• Mood disorders, exacerbation of psychotic disorders in vulnerable people, cannabis use disorders, withdrawal syndrome, neurocognitive impairments, and cardiovascular and respiratory diseases [ 3 ]

Acute and Chronic Effects

The acute and chronic effects of cannabis use have been identified, including:

• Hyperemesis syndrome, impaired coordination and performance, anxiety, suicidal ideations/tendencies, and psychotic symptoms [ 3 ]
• Increased risk of motor vehicle crashes, especially fatal collisions [ 3 ]
• Mood disorders, exacerbation of psychotic disorders in vulnerable people, cannabis use disorders, withdrawal syndrome, neurocognitive impairments, and cardiovascular and respiratory diseases [ 3 ]

Vulnerable Individuals

Certain individuals may be more susceptible to the adverse effects of cannabis use, including:

• Children, who may experience seizures and coma [ 2 ]
• Individuals with a history of psychiatric conditions, who may experience exacerbation of symptoms [ 4 ]
• Individuals with cardiovascular disease, who may experience increased risk of adverse cardiovascular effects [ 5 ]