From the Research
Pediatric Dose of Miralax (Polyethylene Glycol) for Constipation
The pediatric dose of Miralax (polyethylene glycol) for constipation can vary depending on the age and weight of the child.
- The average final dose of polyethylene glycol 3350 in children with dysfunctional elimination was 0.63 gm/kg 1.
- The mean effective dose of polyethylene glycol 3350 in children with chronic constipation was 0.84 g/kg/d, with a range of 0.27-1.42 g/kg/d 2.
- In infants younger than 18 months, the mean effective maintenance dose of polyethylene glycol 3350 was 0.78 g/kg/day, with a range of 0.26-1.26 g/kg/day 3.
- According to international guidelines, polyethylene glycol is the laxative of first choice in the treatment of functional constipation in children, and its efficacy is dose dependent 4.
Key Considerations
- The dose of polyethylene glycol 3350 should be adjusted based on the child's response to therapy and the presence of any adverse effects 2, 3.
- Polyethylene glycol 3350 is generally well tolerated in children, with minor adverse events such as diarrhea and increased gas per rectum reported in some cases 1, 2, 3, 4.
- Monitoring of serum electrolytes should be considered in patients predisposed to water and electrolyte imbalances 4.