How to Take Cobenfy
Take Cobenfy twice daily on an empty stomach—at least 1 hour before a meal or at least 2 hours after a meal—and swallow the capsules whole without opening them. 1
Dosing Schedule and Titration
- Starting dose: Begin with one 50 mg/20 mg capsule twice daily for at least 2 days 1
- Week 1 titration: Increase to one 100 mg/20 mg capsule twice daily for at least 5 days 1
- Maintenance dose: May increase to one 125 mg/30 mg capsule twice daily based on your tolerability and response 1
- Maximum dose: Do not exceed 125 mg/30 mg twice daily 1
Critical Administration Instructions
- Timing with meals: Take each dose at least 1 hour before eating or at least 2 hours after eating 1
- Capsule integrity: Swallow capsules whole—do not open, crush, or chew them 1
- Consistency: Take the medication at the same times each day, approximately 12 hours apart 1
Important Monitoring and Safety Considerations
Before starting Cobenfy, your healthcare provider should check:
- Liver enzyme levels and bilirubin 1
- Heart rate 1
- Urinary function, especially if you have prostate enlargement or bladder problems 1
Watch for these warning signs and contact your provider immediately:
- Urinary problems: Difficulty urinating, weak stream, frequent urination, or inability to empty bladder completely 1
- Liver problems: Yellowing of skin or eyes, dark urine, upper right abdominal pain, nausea, vomiting, or unusual fatigue 1
- Digestive issues: Severe constipation, vomiting, abdominal bloating or pain, or feeling full after eating small amounts 1
- Vision changes: Eye pain or changes in vision, particularly if you have narrow-angle glaucoma 1
Special Populations
If you are elderly (65+ years):
- Start with 50 mg/20 mg twice daily 1
- Your provider may increase the dose more slowly 1
- Maximum recommended dose is 100 mg/20 mg twice daily (lower than standard maximum) 1
- You have higher risk for urinary retention and should be monitored more closely 1
What to Avoid
- Do not drive or operate heavy machinery until you know how Cobenfy affects you, as it may cause dizziness, confusion, hallucinations, or sleepiness 1
- Inform all healthcare providers about any prescription or over-the-counter medications you take, as drug interactions may occur 1
If You Miss a Dose
- Take the missed dose as soon as you remember, following the meal timing requirements 1
- If it's close to your next scheduled dose, skip the missed dose and resume your regular schedule 1
- Do not double doses 1
Overdose
If you take too much Cobenfy, call your healthcare provider, Poison Help Line at 1-800-222-1222, or go to the nearest emergency room immediately 1