From the Research
Ammonium lactate should be applied to dry skin once or twice daily, depending on the severity of the condition, with the most recent and highest quality study suggesting its effectiveness in treating dry skin 1.
Application Frequency and Severity
For most individuals, applying it once daily after bathing when the skin is still slightly damp provides good results. For more severe dry skin, twice-daily application may be necessary.
Mechanism of Action and Product Forms
The medication works best when massaged gently into the affected areas until fully absorbed. Ammonium lactate is typically available as a 12% lotion or cream and should be used consistently for at least 2-4 weeks to see optimal improvement. This compound works through two mechanisms: the ammonium component helps break down the connections between dead skin cells, while the lactic acid (an alpha hydroxy acid) acts as a humectant to draw moisture into the skin and gently exfoliates the outer layer of dry, dead skin cells.
Precautions and Side Effects
It's essential to avoid applying this medication to broken, irritated, or sunburned skin, and to use sunscreen during daytime use as it may increase sun sensitivity. If skin irritation develops or persists, reducing application frequency or discontinuing use may be necessary. According to a study, preparations containing urea, ammonium lactate, or glycerol in different concentrations are considered the best characterized and most effective substances for the care of dry skin 1. Another study compared the effectiveness of 40% urea and 12% ammonium lactate in treating xerosis, showing that both can be effective but with different outcomes 2. However, the most recent and relevant study for guiding clinical practice in this context is from 2009, emphasizing the importance of evidence-based cosmetics for managing conditions like xerosis 1.