From the Research
Ammonium lactate lotion and cream should typically be applied twice daily to dry skin areas, as this frequency has been shown to be effective in treating moderate to severe xerosis 1. For the lotion (usually 12% strength), apply a thin layer to affected areas and rub in thoroughly. The cream formulation (also typically 12%) can be used similarly but provides more intensive moisturization for severely dry skin. Both formulations work best when applied to slightly damp skin after bathing to lock in moisture. Consistency is important, so maintain the twice-daily regimen even after skin improvement begins. If skin irritation occurs, reducing application to once daily may help. Ammonium lactate works through dual mechanisms: the ammonium component helps break down rough, thickened skin while the lactic acid (an alpha hydroxy acid) attracts moisture to the skin and helps maintain hydration. This combination effectively addresses both the roughness and dryness associated with conditions like xerosis, keratosis pilaris, and ichthyosis. Some studies have compared the efficacy of ammonium lactate with other treatments, such as urea, and found that while urea may provide faster improvement in some cases, ammonium lactate is still an effective treatment option 2, 3. Avoid applying to broken, irritated skin or immediately after shaving, and use sunscreen during daytime use as alpha hydroxy acids may increase sun sensitivity. Key considerations for treatment include:
- Applying the lotion or cream to slightly damp skin for better absorption
- Maintaining a consistent application schedule
- Being cautious of potential skin irritation and adjusting application frequency as needed
- Using sunscreen during the day due to increased sun sensitivity from alpha hydroxy acids
- Considering alternative treatments, such as urea, for specific cases or patient needs, as outlined in recent position papers on the diagnosis and treatment of xerosis cutis 3.