What is the most likely cause of an 11-year-old boy's moderate pain in his knees and ankles, with a history of previous trauma, exercise-induced asthma, and normal radiographic findings, currently taking ibuprofen (nonsteroidal anti-inflammatory drug) as needed?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 11, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for the 11-year-old boy with knee and ankle pain

  • Single most likely diagnosis:
    • A) Autoimmune disorder: The patient's symptoms of moderate pain in the knees and ankles, along with mild swelling, warmth, and tenderness to palpation, are consistent with juvenile idiopathic arthritis (JIA), a common autoimmune disorder in children. The absence of abnormalities on X-rays and the presence of full range of motion also support this diagnosis.
  • Other Likely diagnoses:
    • D) Previous trauma: Although the patient had previous sprains, the fact that the pain has persisted for a year and is affecting multiple joints suggests that the trauma may not be the sole cause of his symptoms.
    • E) Viral infection: A viral infection could cause polyarticular pain and swelling, but the chronic nature of the patient's symptoms makes this less likely.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • B) Bacterial infection: Septic arthritis is a medical emergency that requires prompt diagnosis and treatment. Although the patient's symptoms are chronic, it is essential to consider this possibility, especially if the patient's condition worsens or if he develops systemic symptoms such as fever.
    • C) Metabolic bone disease: Conditions like rickets or osteomalacia can cause bone pain and weakness, but they are less common in children and would typically be associated with other symptoms such as bowed legs or muscle weakness.
  • Rare diagnoses:
    • Seronegative spondyloarthropathies: Conditions like ankylosing spondylitis or psoriatic arthritis are rare in children and would typically be associated with other symptoms such as back pain or skin rashes.
    • Lyme disease: Although Lyme disease can cause arthritis, it is less common in children and would typically be associated with other symptoms such as a rash or fever.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.