From the Research
Tranexamic acid is a highly effective treatment for melasma and hyperpigmentation, offering significant benefits in reducing melanin production and inflammation, with oral administration being the most effective method, as shown in a recent study 1. The benefits of tranexamic acid for skin care are numerous, including:
- Inhibiting melanin production and reducing inflammation, effectively lightening dark spots and evening out skin tone
- Providing anti-inflammatory benefits that can help with redness and irritation
- Strengthening the skin barrier and reducing the appearance of post-inflammatory hyperpigmentation from acne
- Being generally well-tolerated by most skin types, including sensitive skin When applied topically, tranexamic acid is typically found in concentrations of 2-5% in serums or creams, and should be used once or twice daily for at least 8-12 weeks to see noticeable results. For more severe cases, oral tranexamic acid (250-500mg twice daily for 8-12 weeks) may be prescribed by dermatologists, though this requires medical supervision due to potential side effects, as noted in a study comparing different dosages 2. The mechanism behind its effectiveness involves blocking the interaction between plasminogen and keratinocytes, which reduces the production of inflammatory mediators that stimulate melanin synthesis in the skin, as discussed in a review of oral tranexamic acid for melasma treatment 3. It's essential to carefully screen patients for personal and familial risk factors for thromboembolism before initiating oral tranexamic acid therapy, as highlighted in a retrospective analysis of oral tranexamic acid in melasma treatment 4.