What causes irritation of the skin on the toes?

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Last updated: April 11, 2025View editorial policy

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Differential Diagnosis for Toe Skin Irritation

  • Single most likely diagnosis
    • Athlete's foot (tinea pedis): This is a common fungal infection that causes skin irritation, itching, and cracking on the toes and feet. It's often seen in individuals who wear tight shoes, sweat excessively, or share footwear.
  • Other Likely diagnoses
    • Eczema (atopic dermatitis): A chronic skin condition characterized by dry, itchy, and inflamed skin, which can affect the toes.
    • Contact dermatitis: An allergic reaction or irritation caused by substances like soap, detergent, or certain materials in shoes.
    • Ingrown toenail: A condition where the nail grows into the surrounding skin, causing redness, swelling, and irritation.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Cellulitis: A bacterial skin infection that can cause redness, swelling, and warmth, and can lead to serious complications if left untreated.
    • Diabetic foot ulcer: A wound or sore on the foot that can be a complication of diabetes, and requires prompt medical attention to prevent infection and amputation.
    • Necrotizing fasciitis: A rare but life-threatening bacterial infection that causes tissue death and requires immediate medical attention.
  • Rare diagnoses
    • Pitted keratolysis: A rare bacterial infection that causes small pits or craters on the skin of the toes.
    • Keratoderma blennorrhagicum: A rare skin condition associated with reactive arthritis, characterized by thickening of the skin on the toes.
    • Erythrasma: A rare bacterial or fungal infection that causes brownish-red patches on the skin, often in the toe webs.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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