Suzetrigine Duration of Action
Suzetrigine is dosed once daily with a 24-hour duration of action, as it should not be taken more than once in 24 hours. 1
Dosing and Administration
The FDA-approved dosing for suzetrigine is 1 tablet daily with a full glass of water, with explicit instructions not to exceed 1 tablet in 24 hours. 1
The tablet must not be divided, crushed, chewed, or dissolved, indicating a controlled-release formulation designed for 24-hour coverage. 1
This once-daily dosing regimen is appropriate for adults and children 12 years and older. 1
Special Population Considerations
Patients with liver or kidney disease should consult a physician before using suzetrigine, as these conditions may alter drug clearance and potentially affect duration of action. 1
Children under 12 years of age require physician consultation for appropriate dosing. 1
Clinical Context: Duration of Action Principles
While specific pharmacokinetic data for suzetrigine's half-life is not provided in the available evidence, the 24-hour dosing interval indicates the drug maintains therapeutic concentrations for this duration. The duration of drug action depends on multiple factors including the absolute amount given, pharmaceutical preparation, drug half-life, and reversibility of drug action. 2
The once-daily dosing requirement clearly establishes that suzetrigine's therapeutic effect persists for approximately 24 hours, making it suitable for convenient once-daily administration without the need for multiple daily doses. 1