What is the management of infusion-related phlebitis in a child?

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Last updated: January 13, 2026View editorial policy

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Management of Infusion-Related Phlebitis in Children

Remove the peripheral venous catheter immediately when phlebitis is identified—this is mandatory, not optional. 1, 2, 3

Immediate Assessment and Catheter Removal

  • Identify phlebitis by clinical signs: warmth, tenderness, erythema, palpable venous cord, or swelling at the IV site 1, 3
  • Remove the catheter as soon as any of these signs develop—do not delay removal hoping symptoms will resolve with the catheter in place 1, 2, 3
  • Visually inspect the site after catheter removal to assess the extent of inflammation 1
  • If exudate is present, submit samples for Gram staining and culture, particularly in immunocompromised children 1

Local Site Care

  • Clean the affected area with an appropriate antiseptic:
    • Preferably use 2% chlorhexidine-based preparation 1
    • Alternatively use 70% alcohol 1
  • Apply appropriate sterile dressing based on site condition:
    • Use sterile gauze for weeping or oozing sites 1
    • Use transparent semi-permeable dressing for dry sites 1
  • Do not submerge the affected area in water until healing is complete 1

Monitoring

  • Evaluate the phlebitis site daily for progression of tenderness, erythema, warmth, and swelling 3
  • Monitor for signs of infection including fever, purulent drainage, and systemic symptoms 3

Placement of New IV Access

  • Use upper extremity sites only for subsequent IV therapy—avoid lower extremity placement as this increases phlebitis risk 1, 3, 4
  • Avoid placing new catheters in the same area where phlebitis occurred 1
  • In pediatric patients, leave catheters in place until IV therapy is completed unless complications occur—do not routinely replace catheters at scheduled intervals as recommended in adults 2
  • Consider using a midline catheter or PICC when IV therapy is expected to exceed 6 days 1

Prevention Strategies for Future IV Insertions

  • Select catheters based on intended purpose and duration of use 1
  • Ensure experienced nurses perform catheter insertion, as insertion by novice nurses increases phlebitis risk 4
  • Avoid steel needles for administration of fluids and medications that might cause tissue necrosis if extravasation occurs 1
  • Keep dressings clean and dry—contaminated dressings increase phlebitis risk 4
  • Consider using in-line filters (1.2-1.5 mm for lipid emulsions or all-in-one mixes; 0.22 mm for aqueous solutions) as particulates in infusion fluid contribute to phlebitis development 5

Critical Pitfalls to Avoid

  • Do not leave the catheter in place once phlebitis develops—this is the most common error and increases risk of progression and infection 1, 2, 3
  • Do not apply topical antimicrobial or antiseptic ointment to the phlebitis site—this provides no benefit and is not recommended 1, 3
  • Do not routinely apply prophylactic topical antimicrobial ointment to insertion sites of peripheral venous catheters 1

Special Considerations for Thrombophlebitis

If the child develops symptomatic catheter-related superficial vein thrombosis (thrombophlebitis extending beyond simple phlebitis), anticoagulation may be considered in specific circumstances:

  • When the catheter is still functioning and the child continues to need venous access 5
  • When symptoms progress despite catheter removal 5
  • However, in most pediatric patients with superficial vein thrombosis, no anticoagulation is appropriate after catheter removal 5

References

Guideline

Management of Phlebitis Caused by IV Insertion

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Treatment of Phlebitis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Peripheral IV Phlebitis Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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