Management of Edema and Phlebitis at IV Site
Remove the peripheral venous catheter immediately when edema and phlebitis are identified. 1, 2
Immediate Actions
Catheter removal is mandatory when signs of phlebitis develop, including warmth, tenderness, erythema, palpable venous cord, or edema. 1 The CDC provides a Category IB recommendation (strong evidence) that leaving the catheter in place increases risk of progression to septic phlebitis and bloodstream infection. 1, 2
After Removal:
- Apply heat and elevation to the affected extremity to reduce inflammation and promote venous drainage. 3
- Do NOT apply topical antimicrobial ointments or creams to the phlebitis site—this provides no benefit and may promote fungal infections and antimicrobial resistance. 1, 2
Daily Monitoring Requirements
Evaluate the phlebitis site daily for the following progression indicators: 2
- Increasing tenderness, erythema, warmth, or swelling 2
- Signs of infection: fever, purulent drainage, systemic symptoms 2
- Development of palpable venous cord indicating thrombophlebitis 1
When to Escalate Treatment
Initiate antibiotics and consider surgical excision if any of the following occur: 3
- Clinical deterioration despite conservative management 3
- Persistent septicemia after 24 hours of antibiotic therapy 3
- Development of systemic signs of infection 3
Septic phlebitis carries a 56% complication rate with an average 14-day hospital stay after diagnosis, making early recognition critical. 3 Staphylococcus aureus (41%) and Group A streptococcus (20%) are the most common causative organisms. 3
Future IV Access Strategy
Use upper extremity sites exclusively for subsequent peripheral IV access. 1, 2 Lower extremity placement significantly increases phlebitis risk in adults and should be avoided. 1
Consider a midline catheter or PICC if IV therapy duration will exceed 6 days, as these have substantially lower phlebitis rates (0.3% for midlines vs. 2.3-53.4% for peripheral IVs). 1, 4, 5, 6, 7
For Short Peripheral Catheters:
- Replace every 72-96 hours in adults to prevent recurrent phlebitis. 1, 4, 7
- In children, leave in place until IV therapy is completed unless complications develop. 1, 4
Critical Pitfalls to Avoid
- Never leave the catheter in place hoping phlebitis will resolve with treatment alone—removal is non-negotiable. 1, 2
- Avoid insertion sites around the elbow joint for future access, as these carry increased phlebitis risk. 8
- Do not use steel needles for medications that could cause tissue necrosis if extravasation occurs. 1
- Avoid contaminated dressings and ensure proper aseptic technique, as these are significant risk factors for phlebitis development. 6