Benadon (Pyridoxine/Vitamin B6) Dosing for Tuberculoma Patients
For tuberculoma patients receiving anti-tuberculosis therapy, pyridoxine (Benadon) should be administered at 100-200 mg daily to prevent and treat neurotoxic side effects from cycloserine and other second-line TB drugs. 1
Standard Pyridoxine Dosing in TB Treatment
The recommended dose is 100-200 mg/day when cycloserine is used as part of the treatment regimen for drug-resistant tuberculosis or tuberculoma 1
This dosing specifically helps prevent central nervous system effects including headache, restlessness, psychosis, and seizures that can occur with cycloserine therapy 1
Pyridoxine may also help prevent peripheral neuritis, though this is a rare adverse effect of cycloserine 1
Clinical Context for Tuberculoma
Tuberculomas represent CNS tuberculosis and typically require treatment with drugs that have good CNS penetration 1
Cycloserine achieves CSF concentrations that approach serum levels, making it valuable for CNS tuberculosis 1
The risk of neurotoxicity with cycloserine increases significantly at doses over 500 mg/day, with seizures occurring in up to 16% of patients at 500 mg twice daily versus only 3% at 500 mg once daily 1
Important Caveats
Do not confuse this question with paracetamol (acetaminophen) dosing - while the expanded question mentions paracetamol, "Benadon" specifically refers to pyridoxine/vitamin B6, not an analgesic 2
If paracetamol is needed for fever/pain management in TB patients, use with extreme caution as isoniazid and rifampin may potentiate acetaminophen hepatotoxicity through cytochrome P450 enzyme induction 2
Monitor neuropsychiatric status at least monthly in patients receiving cycloserine with pyridoxine supplementation 1