Is there an interaction between acetaminophen (Tylenol) with codeine (Tylenol 3) and modafinil?

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From the Research

Yes, there is a potential interaction between Tylenol 3 (acetaminophen with codeine) and modafinil, as modafinil may decrease the effectiveness of codeine by increasing its metabolism in the liver, potentially reducing its pain-relieving effects. When taken together, modafinil induces the CYP3A4 enzyme system, which can accelerate the breakdown of codeine 1. Additionally, both medications can affect the central nervous system, though in different ways. Codeine is a depressant that can cause drowsiness, while modafinil is a stimulant that promotes wakefulness. These opposing effects don't necessarily cancel each other out and could lead to unpredictable responses. Patients taking both medications should monitor for reduced pain control and unusual side effects. The acetaminophen component of Tylenol 3 is not significantly affected by this interaction. If you're prescribed both medications, inform your healthcare provider about all medications you're taking to ensure appropriate dosing and monitoring.

Some key points to consider:

  • Modafinil has been shown to induce several cytochrome P450 isoenzymes, including CYP3A4, which can interact with various drugs, including codeine 1.
  • The interaction between modafinil and codeine may lead to reduced pain control and increased risk of side effects, such as insomnia, headache, and nausea 1.
  • The use of modafinil in patients with sleep disorders, such as obstructive sleep apnea, has been shown to be effective in improving wakefulness and reducing excessive sleepiness 2.
  • However, the potential interaction between modafinil and codeine should be carefully considered, especially in patients with a history of substance abuse or those taking multiple medications 3.

It is essential to note that the evidence for this interaction is based on the pharmacological properties of modafinil and codeine, and further studies are needed to fully understand the clinical implications of this interaction. Nevertheless, patients taking both medications should be closely monitored for potential interactions and side effects.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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