What is the diagnosis for a patient presenting with left facial numbness and weakness, National Institutes of Health (NIH) stroke scale score of 2, complaining of a headache rated 3/10 that starts on top of her head and radiates down to her left jaw, which is relieved by Tylenol (acetaminophen)?

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Differential Diagnosis for Left Facial Numbness and Weakness

Single Most Likely Diagnosis

  • Migraine with aura: The patient's complaint of headache that starts on top of the head and radiates down to the left jaw, accompanied by left facial numbness and weakness, could suggest a migraine with aura. The fact that the headache is manageable with Tylenol also supports this diagnosis, as migraines can often be treated with over-the-counter pain medications.

Other Likely Diagnoses

  • Trigeminal Neuralgia: This condition involves sudden, severe, shock-like pain around the eyes, lips, or nose mainly because of abnormal blood vessels pressing on the trigeminal nerve in the head. The pain of trigeminal neuralgia can be triggered by things like brushing teeth or chewing, which might explain the radiation to the jaw.
  • Temporal Arteritis (Giant Cell Arteritis): Although less common, temporal arteritis could present with headache and facial symptoms, especially if the patient is over 50. However, the absence of jaw claudication, visual disturbances, or systemic symptoms like fever and weight loss makes this less likely.
  • Multiple Sclerosis (MS): MS can cause a wide range of neurological symptoms, including numbness, weakness, and pain. The patient's symptoms could be part of an MS relapse, especially if there's a history of similar episodes or other neurological symptoms.

Do Not Miss Diagnoses

  • Stroke or Transient Ischemic Attack (TIA): Although the patient's symptoms have been persistent and not sudden, it's crucial to consider stroke or TIA, especially if there are any risk factors for vascular disease. Facial numbness and weakness can be symptoms of a stroke, and missing this diagnosis could be catastrophic.
  • Brain Tumor: A tumor in the brain could cause localized symptoms depending on its location. While less likely, a tumor pressing on the trigeminal nerve or affecting the facial nerve could cause the patient's symptoms.
  • Lyme Disease: Neurological manifestations of Lyme disease can include facial palsy (Bell's palsy) and other symptoms like meningitis or encephalitis. Given the potential for severe consequences if untreated, Lyme disease should be considered, especially in endemic areas.

Rare Diagnoses

  • Sarcoidosis: This autoimmune disease can affect any part of the body, including the nervous system, and cause a variety of symptoms, including facial numbness and weakness. However, it would be an uncommon cause of these specific symptoms without other systemic manifestations.
  • Vitamin Deficiencies (e.g., Vitamin B12 Deficiency): Certain vitamin deficiencies can cause neurological symptoms, including numbness and weakness. While rare, these deficiencies can be easily treated and should be considered, especially if the patient has risk factors like a vegan diet without supplementation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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