Can pelvic floor Botulinum toxin (Botox) injections reverse constipation caused by the injections?

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Last updated: April 14, 2025View editorial policy

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From the Guidelines

Botox injections into the pelvic floor are not recommended to reverse constipation caused by other Botox injections, as stated by the American Gastroenterological Association in 2013 1. Instead, managing constipation while waiting for Botox effects to diminish is crucial. Some key strategies for managing constipation include:

  • Increasing fluid intake to 2-3 liters daily
  • Consuming 25-30 grams of fiber daily
  • Engaging in regular physical activity
  • Establishing a consistent bathroom routine Over-the-counter options like polyethylene glycol (Miralax) 17g daily, docusate sodium (Colace) 100mg twice daily, or bisacodyl (Dulcolax) 5-10mg can provide relief. For severe cases, prescription medications such as linaclotide (Linzess) or lubiprostone (Amitiza) may be needed. It's essential to consult with a healthcare provider before starting any treatment for constipation, especially if it's related to previous medical procedures, as they can assess the individual situation and provide personalized guidance. Botox-induced constipation occurs because the toxin can affect smooth muscle function beyond the injection site through systemic absorption, temporarily disrupting normal bowel motility, as noted in the context of its effects on the gastrointestinal system 1. Given the potential risks and limited evidence supporting the use of botulinum toxin injection for refractory defecatory disorders, it is not a recommended treatment outside of clinical trials, according to the American Gastroenterological Association 1.

From the Research

Pelvic Floor Botox Injections and Constipation

  • The use of botulinum toxin type A injections in treating spastic pelvic floor syndrome has been studied, and it has been found that these injections can significantly reduce pelvic floor muscle tension 2.
  • When combined with biofeedback therapy, botulinum toxin type A injections have been shown to be effective in treating pelvic floor muscle spasm syndrome, with significant improvements in anorectal pressure and electromyography indices 2.
  • However, the specific effect of pelvic floor Botox injections on reversing constipation is not directly addressed in the provided studies.
  • Biofeedback therapy has been found to be effective in managing chronic constipation, with response rates between 70% and 80% in clinical trials 3.
  • The efficacy of biofeedback therapy in clinical practice for the management of chronic constipation and fecal incontinence has been demonstrated, with an overall response rate of 76.2% 3.

Biofeedback Therapy for Pelvic Floor Disorders

  • Biofeedback therapy has been found to be effective in treating defecatory disorders, fecal incontinence, and levator ani syndrome 4, 5.
  • The therapy aims to enhance strength, speed, and/or endurance or coordination of voluntary anal sphincter and pelvic floor muscle contractions 5.
  • Biofeedback has demonstrated efficacy in the treatment of chronic constipation with dyssynergic defecation, fecal incontinence, and low anterior resection syndrome 5.
  • The use of biofeedback therapy in combination with other treatments, such as botulinum toxin injections, may be beneficial in managing pelvic floor disorders 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

A Practical Guide to Biofeedback Therapy for Pelvic Floor Disorders.

Current gastroenterology reports, 2019

Research

Biofeedback for Pelvic Floor Disorders.

Clinics in colon and rectal surgery, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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