What is the immediate management for a patient with stage 5 Chronic Kidney Disease (CKD) on regular hemodialysis who experiences a sudden cardiac arrest during the return of blood when only a manual defibrillator is available?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: January 16, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Immediate Management of Cardiac Arrest During Hemodialysis with Manual Defibrillator

If only a manual defibrillator is available during cardiac arrest in a hemodialysis patient, immediately initiate high-quality CPR while a second provider charges the manual defibrillator, briefly pause compressions to "clear" and deliver the shock, then immediately resume CPR starting with chest compressions for 2 minutes before the next rhythm check. 1, 2

Initial Response Algorithm

Stop dialysis immediately and activate emergency response while simultaneously beginning CPR with cycles of 30 compressions and 2 breaths at a rate of 100-120 compressions per minute with depth of at least 2 inches. 1, 3

Manual Defibrillator Workflow (Requires ACLS-Certified Operator)

  • First provider begins CPR immediately while second provider retrieves and charges the manual defibrillator to appropriate energy level (biphasic: 120-200 Joules per manufacturer recommendation; monophasic: 360 Joules). 1

  • Minimize interruption in compressions by having the second provider charge the defibrillator while CPR continues, pausing only briefly to "clear" the patient and deliver the shock. 1

  • Resume CPR immediately after shock delivery without checking pulse or rhythm—this is critical as each interruption decreases coronary and cerebral perfusion pressure. 1, 2

  • Continue CPR for full 2-minute cycles before pausing briefly (less than 10 seconds) to check rhythm on the manual defibrillator monitor. 1, 2

  • Change compressors every 2 minutes at the time of rhythm checks to prevent fatigue and maintain compression quality. 1, 2

Dialysis-Specific Considerations

Assume hyperkalemia until proven otherwise in any dialysis patient with cardiac arrest, as 61% of cardiac deaths in dialysis patients are from arrhythmic mechanisms, with hyperkalemia being the most common precipitant. 1, 3

Immediate Electrolyte Management

  • Administer calcium chloride 10% 10 mL IV (or calcium gluconate 10% 30 mL IV) immediately if hyperkalemia is suspected or ECG shows peaked T waves, widened QRS, or sine wave pattern. 3

  • Give sodium bicarbonate 50 mEq IV bolus to shift potassium intracellularly. 3

  • Administer regular insulin 10 units IV with dextrose 50% 50 mL (D50W) to further shift potassium intracellularly. 3

Standard ACLS Medications

  • Establish IV/IO access and administer epinephrine 1 mg IV/IO every 3-5 minutes for all cardiac arrest rhythms. 1, 3

  • For refractory VF/pulseless VT, administer amiodarone 300 mg IV/IO bolus (second dose 150 mg) or lidocaine as alternative antiarrhythmic. 1, 3

Critical Prognostic Context

The combination of cardiac arrest during dialysis carries 30% overall survival to hospital discharge, with 62% of dialysis-related cardiac arrests presenting as shockable rhythms (VF/VT) that respond better to defibrillation. 1, 3 Mortality increases 7-10% per minute without defibrillation, making rapid manual defibrillation by ACLS-certified operators essential. 1

Why Manual Defibrillators Require ACLS Training

Manual defibrillators require operators certified in ACLS because they demand more maintenance, require manual rhythm interpretation, and necessitate manual energy selection—unlike AEDs which automatically analyze rhythm and select appropriate energy. 1 However, manual defibrillators are appropriate devices for dialysis units when operated by properly trained staff. 1

Common Pitfalls to Avoid

  • Never check pulse or rhythm immediately after shock delivery—this wastes critical time when chest compressions should be ongoing. 1, 2

  • Never interrupt compressions for frequent rhythm checks—keep rhythm checks brief (less than 10 seconds) and only perform every 2 minutes. 1, 2

  • Do not treat hypokalemia or hypocalcemia without checking and correcting magnesium first, as these will be refractory to replacement without adequate magnesium. 3, 4

  • Avoid moving the patient from the dialysis chair to the floor unless absolutely necessary—51% of experienced dialysis technicians indicate optimal CPR can be performed directly in the dialysis chair, and moving wastes critical time. 5

Post-ROSC Management

After achieving return of spontaneous circulation (ROSC), obtain urgent 12-lead ECG and check stat electrolytes (K, Mg, Ca), glucose, and arterial blood gas. 3 Maintain potassium 3.5-4.5 mmol/L as this range shows the lowest risk of VF, cardiac arrest, or death in dialysis patients. 3, 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Rhythm and Pulse Checks During CPR

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Management of Cardiac Arrest During Dialysis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Tachycardia in Dialysis Patients

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Cardiac Arrest in Outpatient Hemodialysis Units: A National Cross-Sectional Survey of Dialysis Technicians.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2025

Related Questions

What are the key concepts in managing chronic kidney disease (CKD)?
What is the best course of management for a patient in their late 70s with a history of COPD, coronary artery disease, hypertension, hyperlipidemia, hypothyroidism, chronic kidney disease stage 3, protein-calorie malnutrition, depression, generalized anxiety disorder, cerebral infarction, left hemiplegia/hemiparesis, blindness, tobacco use disorder, neuralgia, neuritis, and current acute kidney injury, sepsis, and atypical pneumonia?
What laboratory test should be ordered first for a patient with chronic kidney disease (CKD) presenting with fatigue, weakness, and occasional shortness of breath?
What is the immediate management for a patient who experiences cardiac arrest after undergoing hemodialysis?
What is the most common cause of death in a patient with Chronic Kidney Disease (CKD)?
What is the preferred treatment between Benzydamine (benzydamine hydrochloride) and flurbiprofen (Non-Steroidal Anti-Inflammatory Drug (NSAID)) for a patient with acute tonsillitis?
What is the treatment plan for a patient with menorrhagia (heavy menstrual bleeding) and regular menstrual cycles (N92.0)?
What could be causing my symptoms and what should I do since I'm really concerned something is going on with my health?
What is the relationship between rare alcohol consumption and subsequent supraventricular tachycardia (SVT) or tachycardia in a patient with no other known cardiac conditions?
I'm a male of reproductive age with normal testosterone levels, normal sperm parameters, and a normal Follicle-Stimulating Hormone (FSH) level, but I've noticed my testicles feeling soft and mushy for about a month, could I be experiencing ongoing testicular atrophy?
What is the recommended follow-up care for a patient after undergoing Bartholin's abscess marsupialization?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.