From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
For prophylactic use, Keflex (cephalexin) is typically dosed at 500 mg orally twice or thrice daily, as this regimen has been shown to be effective in treating uncomplicated lower urinary tract infections due to non-extended-spectrum beta-lactamase-producing Enterobacteriaceae, with good early bacteriological and clinical cures comparable to many traditionally first-line agents 1.
Key Considerations
- Cephalexin can be used as a fluoroquinolone-sparing alternative, which is beneficial in reducing the development of antibiotic resistance.
- The dosing frequency of cephalexin can be either twice or thrice daily, making it a convenient option for patients.
- Reliable antimicrobial susceptibility test interpretative criteria for cephalexin are provided by several reputable organizations, including the Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) 1.
Important Notes
- It is essential to note that the efficacy of cephalexin may vary depending on the specific bacterial cause of the infection and local resistance patterns.
- Patients should be monitored for signs of infection or adverse effects, and the treatment regimen should be adjusted as necessary based on clinical response and susceptibility testing results.
- Preventive measures, such as proper hygiene and avoiding prolonged engorgement, can help reduce the need for antibiotic prophylaxis.