Prevalence of Shortness of Breath in COVID-19
Shortness of breath is an extremely common complication of COVID-19, occurring as one of the most frequent symptoms during acute infection and persisting in a substantial proportion of patients with long COVID.
Acute COVID-19 Phase
Prevalence in Hospitalized Patients
- Dyspnea is present in 69.8% of COVID-19 patients and represents one of the cardinal symptoms alongside fever and cough 1.
- Among critically ill patients requiring ICU admission, 60-70% develop acute hypoxemic respiratory failure from acute respiratory distress syndrome (ARDS), making it the most common complication 2.
- Shortness of breath is strongly associated with disease severity, with an odds ratio of 2.43 for severe COVID-19 1, 3.
Severity Classification
- Severe COVID-19 (occurring in 13.8-14% of cases) is specifically defined by dyspnea, respiratory rate ≥30 breaths per minute, oxygen saturation ≤93%, PaO2/FiO2 ratio <300 mmHg, and lung infiltrates >50% within 24-48 hours 2, 1.
- The median time from symptom onset to severe hypoxemia requiring ICU admission is approximately 7-12 days 2.
Pediatric Considerations
- In hospitalized children, shortness of breath is among the most common presenting symptoms along with fever, nausea/vomiting, and cough 2.
- Children generally have milder presentations than adults, with up to 45% being asymptomatic 2.
Long COVID (Post-Acute COVID-19 Syndrome)
Persistent Respiratory Symptoms
- More than one-third of COVID-19 patients develop symptoms persisting beyond 3 months after SARS-CoV-2 infection, with breathlessness being a frequently cited symptom 4.
- Shortness of breath persists for at least 7 months in 40% of patients with long COVID, making it one of the most common long-term respiratory sequelae 2.
- Respiratory conditions occur twice as often in COVID-19 survivors as in the general population 2.
Mechanisms of Persistent Dyspnea
- Some patients have residual pulmonary disorders with abnormal pulmonary function tests to explain their dyspnea 5.
- Others have dyspnea out of proportion to measurable lung function changes, with abnormal respiratory patterns referred to as dysfunctional breathing 5.
- 90% of patients with self-assessed respiratory dysfunction at 4 months post-hospitalization had one or several objectively measured respiratory function abnormalities 6.
High-Risk Populations
Pre-existing Conditions
- Patients with pre-existing respiratory or cardiovascular conditions face significantly worse outcomes 2, 3.
- Respiratory disease increases the odds of critical/mortal COVID-19 by 5.15-fold (OR = 5.15,95% CI 2.51-10.57) 3.
- Cardiovascular disease increases the odds of critical/mortal COVID-19 by 5.19-fold (OR = 5.19,95% CI 3.25-8.29) 3.
- Patients with hypertension, diabetes, and chronic lung disease are at substantially higher risk for severe complications 2.
Age and Comorbidity Impact
- Critically ill patients with COVID-19 are older and have more comorbidities including hypertension and diabetes compared to non-critically ill patients 2.
- Age over 65 years increases the odds of disease progression by 6.06-fold (OR = 6.06,95% CI 3.98-9.22) 3.
Clinical Implications
Warning Signs Requiring Immediate Attention
- Oxygen saturation ≤93-94% on room air, respiratory rate ≥30 breaths per minute, or lung infiltrates >50% require immediate escalation of care 7.
- Severe respiratory distress, including grunting or severe chest indrawing, is a critical warning sign 7.
- Patients may develop hypoxemia without respiratory distress, particularly elderly patients 2.
Multidimensional Assessment Needed
- Patients with remaining respiratory symptoms may benefit from multidimensional measuring of breathing movement, thoracic expansion, and respiratory muscle strength along with traditional measurements 6.
- Decreased thoracic expansion was observed in 62% of patients, abnormal respiratory movements in 58%, and decreased vital capacity in 40% at 4 months post-discharge 6.
Long-Term Cardiovascular Sequelae
- A significant proportion of patients experience long-term complications 4 weeks from index infection, including chest pain, palpitations, and dyspnea related to cardiac dysfunction 2.
- New-onset right ventricular dysfunction can result from acute pulmonary embolism or strain from ARDS and elevated pulmonary artery pressures 2.