What is the cause of lateral foot swelling in the sinus tarsi?

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Last updated: April 15, 2025View editorial policy

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Differential Diagnosis for Lateral Foot Swelling and Sinus Tarsi

  • Single Most Likely Diagnosis
    • Sinus tarsi syndrome: This condition is characterized by pain and swelling in the lateral foot, particularly in the area of the sinus tarsi, which is a small canal on the outside of the ankle. It is often caused by overuse or repetitive strain on the foot and ankle, making it a common issue in athletes or individuals who engage in activities that involve running or jumping.
  • Other Likely Diagnoses
    • Peroneal tendonitis: Inflammation of the peroneal tendons, which run along the lateral aspect of the ankle, can cause swelling and pain in the area, including the sinus tarsi.
    • Cuboid syndrome: This condition involves the cuboid bone in the midfoot and can cause pain and swelling on the lateral side of the foot, potentially radiating to the sinus tarsi area.
    • Lateral ankle sprain: Although more commonly associated with acute trauma, chronic or recurrent lateral ankle sprains can lead to swelling and pain in the lateral foot, including the sinus tarsi.
  • Do Not Miss Diagnoses
    • Osteoid osteoma: A benign bone tumor that can cause severe pain, often worse at night, and swelling. Although rare, it's crucial to consider due to its potential for significant morbidity if left untreated.
    • Ewing's sarcoma: A rare type of cancer that can present with swelling and pain in the foot or ankle. Early diagnosis is critical for effective treatment.
    • Infection (osteomyelitis or septic arthritis): Infections in the bone or joint can cause swelling, pain, and systemic symptoms like fever. Prompt diagnosis and treatment are essential to prevent serious complications.
  • Rare Diagnoses
    • coalition of the subtalar joint: An abnormal connection between the bones of the subtalar joint, which can cause pain and stiffness in the foot and ankle, including the area around the sinus tarsi.
    • Rheumatologic conditions (e.g., rheumatoid arthritis, psoriatic arthritis): These conditions can cause widespread joint pain and swelling, including in the foot and ankle, though they are less common causes of isolated lateral foot swelling and sinus tarsi pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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