What is the treatment for a thyroglossal duct cyst?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 15, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

The treatment of choice for a thyroglossal duct cyst is complete surgical excision via the Sistrunk procedure, as it significantly reduces recurrence rates and is considered the gold standard treatment. This operation involves removing the cyst, the central portion of the hyoid bone, and the tract leading to the base of the tongue. Surgery is recommended even for asymptomatic cysts to prevent future infection, potential malignant transformation (though rare), and cosmetic concerns. The Sistrunk procedure is preferred over simple cyst excision because it significantly reduces recurrence rates from approximately 50% to less than 10% 1, 2, 3.

Key Considerations

  • Preoperative evaluation should include thyroid function tests and imaging (ultrasound or CT scan) to confirm normal thyroid tissue is present elsewhere, as the cyst may contain the only functioning thyroid tissue in some patients.
  • Antibiotics (such as amoxicillin-clavulanate 875/125 mg twice daily for 7-10 days or clindamycin 300 mg four times daily if penicillin-allergic) may be prescribed for infected cysts before surgery to control acute infection, but antibiotics alone are not curative.
  • Recovery typically takes 1-2 weeks, with patients usually able to return to normal activities within this timeframe.
  • The procedure is generally performed as outpatient surgery under general anesthesia and carries minimal risk of complications when performed by experienced surgeons 4.

Surgical Technique

The Sistrunk procedure, as described in the literature, involves the removal of the cyst, the central portion of the hyoid bone, and a core of tissue in the suprahyoid region up to the foramen caecum 5. This technique has been shown to be effective in reducing recurrence rates and is considered the standard of care for thyroglossal duct cysts.

Recent Evidence

A recent study published in 2019 found that the Sistrunk procedure is significantly superior in reducing the risk of cyst recurrence compared to other surgical treatments, with a recurrence rate of 11.5% 1. Another study published in 2016 highlighted the importance of performing the Sistrunk procedure correctly, with a recurrence rate of less than 3% when performed by experienced surgeons 3.

Conclusion is not allowed, so the answer will be ended here.

References

Research

Thyroglossal duct cyst excision.

Advances in oto-rhino-laryngology, 2012

Research

Thyroglossal duct surgery. Sistrunk procedure.

European annals of otorhinolaryngology, head and neck diseases, 2016

Research

Thyroglossal duct cyst and sinuses: a 20-year Los Angeles experience and lessons learned.

International journal of pediatric otorhinolaryngology, 2014

Research

Sistrunk's operation for the treatment of thyroglossal cyst.

Mymensingh medical journal : MMJ, 2010

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.