From the Research
Bergamot should be avoided by individuals taking medications metabolized by CYP3A4 enzymes, those with photosensitivity disorders, pregnant and breastfeeding women, individuals with low blood pressure, citrus allergies, and liver conditions, as well as before surgery, due to its potential to cause dangerous interactions and exacerbate existing conditions. The use of bergamot is contraindicated in several groups of people due to its potential to cause adverse effects.
- Individuals taking medications metabolized by CYP3A4 enzymes, such as statins, benzodiazepines, and certain antidepressants, should avoid bergamot as it can inhibit these enzymes and potentially cause dangerous drug interactions 1.
- People with photosensitivity disorders should not use bergamot oil on their skin before sun exposure, as it contains bergapten, which can cause phototoxic reactions including severe burns and hyperpigmentation 2.
- Pregnant and breastfeeding women should exercise caution with bergamot supplements due to insufficient safety data 3.
- Those with low blood pressure should be careful as bergamot may have hypotensive effects 4.
- Individuals with citrus allergies should avoid bergamot entirely to prevent allergic reactions.
- Before surgery, bergamot should be discontinued at least two weeks prior as it may affect blood clotting and interact with anesthesia medications.
- Anyone with liver conditions should consult healthcare providers before using bergamot since it's metabolized in the liver and could potentially exacerbate liver issues. These contraindications exist because bergamot contains potent bioactive compounds including furocoumarins and flavonoids that can significantly interact with bodily processes and medications. It is essential to consider these contraindications to minimize the risk of adverse effects and ensure safe use of bergamot. The potential benefits of bergamot, such as its anti-inflammatory, antioxidant, and anticancer properties, should be weighed against the potential risks, and individuals should consult with healthcare providers before using bergamot, especially if they have any underlying medical conditions or are taking medications.