What is the cause of low Oral Contraceptive Pills (OCP) efficacy in a 24-year-old female experiencing mood changes while taking Tri Lo Mili (norgestimate and ethinyl estradiol)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 15, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

If you're experiencing low estrogen levels (OCP) and mood changes while taking Tri Lo Mili, I recommend speaking with your healthcare provider about switching to a different birth control pill with a higher estrogen content, such as Sprintec or Ortho-Cyclen, which could help stabilize your mood while still providing effective contraception. Tri Lo Mili is an ultra-low-dose combination pill containing ethinyl estradiol (25 mcg) and norgestimate in varying amounts. Your provider might consider prescribing a pill with 30-35 mcg of estrogen, which could help alleviate symptoms similar to premenstrual syndrome, including irritability, anxiety, or depression, as estrogen affects neurotransmitters like serotonin and dopamine that regulate mood 1. Some women are more sensitive to these hormonal changes, particularly younger women who may need slightly higher hormone levels for optimal well-being while still maintaining contraceptive benefits.

  • Key considerations for switching birth control pills include:
    • Monitoring for any changes in mood or side effects
    • Using a backup contraceptive method, such as condoms, for the first 7 days after switching
    • Following up with your healthcare provider to assess the effectiveness of the new birth control pill and address any concerns
  • It's essential to note that individual responses to hormonal changes can vary, and what works for one person may not work for another, as seen in studies examining the effects of different hormone combinations on postmenopausal symptoms and bone density 2, 3, 4, 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.