Brand Names for Levonorgestrel-Estradiol Combinations
The provided evidence does not contain specific brand name information for levonorgestrel combined with estradiol as a regular contraceptive product currently marketed in the United States.
Key Distinction: Estradiol vs. Ethinyl Estradiol
The combination of levonorgestrel with estradiol (not ethinyl estradiol) has been studied primarily in contraceptive vaginal ring formulations, but these are not currently available as FDA-approved products in the U.S. market 1.
Historical Context
- Research from the 1980s examined contraceptive vaginal rings releasing levonorgestrel and estradiol (not ethinyl estradiol), with rings releasing approximately 250-290 mcg levonorgestrel and 150-180 mcg estradiol daily 2.
- These levonorgestrel-estradiol vaginal rings were compared to oral contraceptives but were never brought to market as commercial products 2.
Currently Available Levonorgestrel Combinations
If the question pertains to levonorgestrel combined with ethinyl estradiol (the synthetic estrogen used in modern contraceptives), multiple brand names exist:
- Oral contraceptives: Various formulations contain 100-150 mcg levonorgestrel with 20-30 mcg ethinyl estradiol 3, 4, 5.
- Contraceptive patch: A low-dose levonorgestrel and ethinyl estradiol patch has been studied and approved 6.
Clinical Caveat
The specific combination of levonorgestrel with estradiol (rather than ethinyl estradiol) does not have a current brand name product available in the U.S. market 1. If prescribing contraception, clinicians should specify whether they are seeking levonorgestrel with ethinyl estradiol (widely available) or the uncommon levonorgestrel-estradiol formulation (not commercially available).