From the Guidelines
Creatinine supplements should be avoided as they can potentially harm renal function and serve no beneficial purpose. When considering the impact of creatinine on renal function, it's essential to distinguish between creatine and creatinine, as they are often confused due to their similar names. Creatine supplements, commonly used by athletes, are generally considered safe for individuals with normal kidney function when taken at recommended doses [@\1@]. However, creatinine is a waste product that healthy kidneys filter from the blood, and supplementing it would not provide any benefits. In fact, taking creatinine directly could artificially elevate blood creatinine levels, potentially leading to misdiagnosis of kidney problems during medical testing. Furthermore, if a patient is taking creatine and has evidence of renal dysfunction, it is necessary to discontinue this supplement [@\1@].
Key Considerations
- Creatinine is a waste product that should not be supplemented.
- Creatine supplements, when taken at recommended doses, are generally safe for individuals with normal kidney function.
- Taking creatinine directly could stress the kidneys, especially in people with pre-existing kidney disease.
- It is crucial to consult with a healthcare provider before starting any supplement regimen, particularly if you have any kidney issues.
Recommendations for Athletes and Individuals with Kidney Concerns
- Focus on properly dosed creatine monohydrate rather than creatinine for athletic performance support.
- Always consult with a healthcare provider before starting any supplement regimen, especially if you have kidney issues.
- Monitor kidney function regularly if you are taking creatine supplements and have pre-existing kidney disease.
From the FDA Drug Label
Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function
The creatinine supplement may affect renal function, as significant impairment of renal function is a contraindication for the drug, and the drug is substantially excreted by the kidney. Patients with impaired renal function are at a greater risk of toxic reactions to the drug 1.
From the Research
Effects of Creatinine Supplement on Renal Function
- Creatine supplements may cause a temporary increase in serum creatinine levels, which can be misinterpreted as a sign of kidney disease 2.
- However, studies have shown that creatine supplementation does not significantly alter serum creatinine levels or plasma urea values, indicating that it does not induce renal damage 3.
- The use of creatine supplements in people with chronic renal disease or those taking potentially nephrotoxic medications is not recommended, as it may increase the risk of renal dysfunction 2, 4.
- Some case reports have linked creatine supplementation to renal dysfunction, but these are rare and often associated with high doses or pre-existing kidney problems 5, 4.
Safety and Tolerance of Creatine Supplementation
- Creatine supplementation is generally considered safe and well-tolerated, especially at recommended dosages (3-5 g/day or 0.1 g/kg of body mass/day) 6.
- However, high doses or long-term use of creatine supplementation may be associated with an increased risk of renal dysfunction, particularly in individuals with pre-existing kidney problems 4.
- The safety of creatine supplementation in children and adolescents has not been established, and further research is needed to determine its effects on renal function in these populations 4.