From the Guidelines
Taking both meloxicam and Aleve (naproxen) together is not recommended due to the increased risk of side effects without providing additional pain relief for osteoarthritis knee pain. You should choose one NSAID rather than combining them. If you're currently prescribed meloxicam by your doctor, it's best to continue with that medication (typically 7.5-15 mg once daily) and discontinue the Aleve 1. Using two NSAIDs simultaneously can significantly increase your risk of gastrointestinal bleeding, kidney problems, and cardiovascular issues.
Some key points to consider:
- The EULAR recommendations suggest that paracetamol is effective in the treatment of knee OA and may be considered as a first-line treatment option 1.
- NSAIDs, such as meloxicam and naproxen, are also effective in managing knee OA, but they are associated with a higher risk of gastrointestinal side effects compared to paracetamol 1.
- Topical NSAIDs may be a useful alternative for patients who are unable to take oral NSAIDs or who experience gastrointestinal side effects 1.
- Intra-articular steroid injections may be considered for acute exacerbations of knee pain, especially if accompanied by effusion 1.
If your current pain management is inadequate, consult your healthcare provider about alternative options such as acetaminophen, topical NSAIDs, physical therapy, or other treatments rather than combining NSAIDs. Your provider might also consider adjusting your meloxicam dosage if appropriate for your situation. Always take NSAIDs with food to reduce stomach irritation and stay well-hydrated while using these medications.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Osteoarthritis Pain Management
- The patient is taking meloxicam and Aleve (naproxen) for osteoarthritis (OA) pain in the knees.
- Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that has been shown to be effective in managing OA pain 2.
- However, long-term use of NSAIDs, including meloxicam, has been associated with adverse events such as gastrointestinal, cardiovascular, and renal toxicity 3.
Safety Concerns
- The use of meloxicam and other NSAIDs has been linked to an increased risk of acute myocardial infarction, heart failure, and hemorrhagic stroke 3.
- Patients with OA who take NSAIDs, including meloxicam, should be monitored for potential adverse events, especially those with comorbid conditions such as hypertension, heart failure, and diabetes mellitus 3.
Alternative Treatment Options
- Other treatment options for OA pain include acetaminophen, opioids, and nerve growth factor antibodies, each with its own mechanism of action and potential risks and benefits 4.
- Topical NSAIDs, COX-2 inhibitors, and intra-articular corticosteroids are also recommended as first-line treatments for OA, but may have increased risks in patients with certain comorbidities 5.
Pharmaceutical Treatment Guidelines
- The pharmaceutical management of OA is a constantly evolving field, with emerging treatments and updated guidelines 5.
- Clinicians should consider the latest evidence and recommendations to make informed decisions about treatment plans for patients with OA, taking into account individual patient needs and comorbidities 5.