Is the arthrosis consistent with degenerative joint disease (DJD)?

From the Guidelines

Arthrosis is indeed consistent with degenerative changes in joints, as it represents a degenerative joint disease characterized by the breakdown of cartilage and underlying bone. This condition typically develops gradually over time as joint tissues deteriorate through normal wear and tear, aging processes, or following injury, as noted in the 2019 American College of Rheumatology guideline for the management of osteoarthritis of the hand, hip, and knee 1. The degenerative changes in arthrosis include:

• Cartilage thinning
• Bone spur formation
• Synovial inflammation
• Joint space narrowing These structural alterations lead to the classic symptoms of joint pain, stiffness, reduced range of motion, and sometimes swelling. Management typically involves a combination of physical therapy, weight management, pain medications like acetaminophen or NSAIDs, and in some cases, corticosteroid injections. The connection between arthrosis and degenerative changes is fundamental to understanding the condition's pathophysiology, as the term "degenerative" directly describes the progressive deterioration of joint structures that defines arthrosis, affecting an estimated 302 million people worldwide, as reported in the study 1.

The key principles of managing osteoarthritis, as outlined in the guideline 1, apply to all patients with OA and involve a comprehensive approach to treatment. Some recommendations are specific to a particular joint or patient population, but the underlying goal is to alleviate symptoms, improve function, and enhance quality of life. The most recent and highest quality evidence, as presented in the 2020 study 1, supports the use of a multifaceted treatment plan to address the degenerative changes associated with arthrosis.

In terms of specific treatment options, the guideline 1 provides recommendations for the management of osteoarthritis in different joints, including the hip, knee, and hand. For example, the use of NSAIDs, such as ibuprofen or naproxen, is recommended for the management of pain and inflammation in patients with OA. However, the choice of treatment should be individualized based on the patient's specific needs and medical history, as emphasized in the study 1.

Overall, the relationship between arthrosis and degenerative changes is well-established, and the management of this condition requires a comprehensive and patient-centered approach, as supported by the highest quality evidence available 1.

From the FDA Drug Label

In patients with osteoarthritis, the therapeutic action of naproxen has been shown by a reduction in joint pain or tenderness, an increase in range of motion in knee joints, increased mobility as demonstrated by a reduction in walking time, and improvement in capacity to perform activities of daily living impaired by the disease

Naproxen has been shown to be effective in treating osteoarthritis, which is consistent with degenerative changes. The drug has been demonstrated to reduce joint pain and tenderness, increase range of motion, and improve mobility in patients with osteoarthritis 2.

From the Research

Definition and Causes of Arthrosis

• Arthrosis is a term used to describe a group of conditions that cause joint pain and inflammation, with the most common type being osteoarthritis (OA) 3, 4, 5, 6, 7.
• OA is characterized by the degeneration of joint cartilage and underlying bone, leading to pain, stiffness, and limited mobility 3, 5, 7.

Relationship between Arthrosis and Degenerative Changes

• Degenerative changes are a hallmark of OA, with the wear and tear of joint cartilage and bone leading to the development of the condition 3, 5, 7.
• The degenerative changes associated with OA can lead to the formation of bone spurs, cartilage loss, and inflammation, resulting in pain and stiffness 5, 7.
• The progression of OA can be influenced by various factors, including age, weight, and lifestyle, with degenerative changes playing a key role in the development and progression of the condition 3, 4, 6, 7.

Treatment Options for Arthrosis

• Treatment options for OA include pharmaceuticals, such as nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and opioids, as well as surgical interventions, such as joint replacement 3, 4, 6, 7.
• The goal of treatment is to manage symptoms, improve function, and slow disease progression, with the choice of treatment depending on the severity of the condition and the individual's overall health 3, 4, 6, 7.
• Conservative management, including physical therapy, weight loss, and lifestyle modifications, can also play an important role in managing OA symptoms and slowing disease progression 5, 7.