From the FDA Drug Label
Aspiration pneumonia is a common cause of morbidity and mortality in elderly patients, in particular those with advanced Alzheimer's dementia. Quetiapine and other antipsychotic drugs should be used cautiously in patients at risk for aspiration pneumonia.
- 18 Dysphagia Esophageal dysmotility and aspiration have been associated with antipsychotic drug use.
Dysphagia 2% 0%
Oropharyngeal dysphagia is not explicitly mentioned, however dysphagia is listed as an adverse reaction.
- Dysphagia can be related to oropharyngeal dysphagia.
- The FDA label does mention that esophageal dysmotility and aspiration have been associated with antipsychotic drug use, which can be related to dysphagia.
- The label advises to use quetiapine cautiously in patients at risk for aspiration pneumonia.
- Dysphagia was reported in 2% of patients treated with quetiapine 1.
From the Research
Yes, Seroquel (quetiapine) can cause oropharyngeal dysphagia, which is difficulty swallowing affecting the mouth and throat, as neuroleptics like Seroquel have been identified as potentially harmful for swallowing function 2. This side effect is relatively uncommon but is documented in patients taking this antipsychotic medication. Dysphagia may occur due to Seroquel's anticholinergic properties, which can reduce saliva production and affect muscle coordination in the throat. Additionally, Seroquel can cause extrapyramidal symptoms that may impact the muscles involved in swallowing.
The risk of oropharyngeal dysphagia appears to be dose-dependent, with higher doses potentially increasing the likelihood of experiencing this side effect. Patients taking Seroquel who develop symptoms such as difficulty swallowing, choking sensation, or food getting stuck should report these symptoms to their healthcare provider immediately.
- The provider may consider dose adjustment, switching to a different medication, or implementing swallowing strategies.
- Elderly patients may be particularly vulnerable to this side effect.
- Staying well-hydrated and taking the medication with adequate water can sometimes help minimize swallowing difficulties.
- Early screening and assessment of videofluoroscopic swallowing were recommended for assessing the presence of dysphagia 3.
- Therapeutic methods, such as tongue and pharyngeal muscle strengthening exercises and neuromuscular electrical stimulation with swallowing therapy, were effective in improving swallowing function and quality of life in patients with dysphagia 3.
It is essential to note that while the evidence suggests a potential link between Seroquel and oropharyngeal dysphagia, the overall quality of evidence is limited, and more research is needed to fully understand this relationship 4. However, given the potential risks, it is crucial for healthcare providers to monitor patients taking Seroquel for signs of dysphagia and adjust treatment plans accordingly.