What is Adipex (Phentermine)?

From the Guidelines

Adipex, also known as phentermine, should be prescribed at a dosage of 15 to 37.5 mg orally once daily in the morning for short-term weight loss in overweight or obese individuals, with careful consideration of potential side effects and contraindications, as evidenced by a 28-week, randomized, controlled trial comparing phentermine/topiramate extended-release with phentermine monotherapy and topiramate monotherapy in adults with obesity 1. When considering the use of Adipex, it is essential to weigh the potential benefits against the risks, particularly in patients with pre-existing medical conditions.

• The medication is associated with a significant weight loss, with 46% of subjects achieving 5% weight loss and 20.8% achieving 10% weight loss at 28 weeks, compared to placebo 1.
• Common side effects of phentermine include dry mouth, difficulty sleeping, dizziness, and irritability, and it should not be used with monoamine oxidase inhibitors or other sympathomimetic amines 1.
• Appropriate candidates for phentermine include patients with obesity who need assistance with appetite suppression, but it is generally used in younger patients without evidence of active or unstable coronary disease, or uncontrolled hypertension 1.
• Patients who have anxiety or insomnia might feel their condition is exacerbated by phentermine, and would not be ideal candidates 1. The use of Adipex should be carefully monitored, and patients should be informed about the potential risks and benefits, as well as the importance of adhering to the prescribed dosage and treatment duration to minimize the risk of tolerance and dependence.

From the FDA Drug Label

Phentermine Hydrochloride is a sympathomimetic amine anorectic indicated as a short-term adjunct (a few weeks) in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index greater than or equal to 30 kg/m 2, or greater than or equal to 27 kg/m 2 in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia). The drug is known by the brand name Adipex. Key points about phentermine include:

• It is used for short-term weight reduction.
• It is used in conjunction with exercise, behavioral modification, and caloric restriction.
• It is indicated for patients with a body mass index (BMI) of 30 kg/m2 or higher, or 27 kg/m2 or higher with other risk factors. 2

From the Research

Adipex Overview

• Adipex, also known as phentermine, is a medication used for weight loss in obese individuals 3, 4, 5.
• It is often prescribed in combination with other medications, such as topiramate, to enhance its effectiveness 3, 4.

Efficacy of Adipex

• Studies have shown that phentermine-topiramate is associated with significant weight loss, with a median weight loss of 8.8 kg at 1 year 4.
• Phentermine-topiramate has also been shown to be effective in achieving at least 5% weight loss, with an odds ratio of 9.22 compared to placebo 4.
• However, it is essential to note that phentermine can be associated with potential dependency and side effects, necessitating careful consideration and monitoring 5.

Comparison with Other Weight Loss Medications

• Adipex has been compared to other weight loss medications, including orlistat, liraglutide, and naltrexone-bupropion, in terms of efficacy and safety 3, 4, 5.
• Semaglutide, a newer medication, has been shown to produce more significant weight loss, with an average of 15% weight loss at 1 year 6.
• The choice of medication should be tailored to the individual's specific needs and health status, taking into account potential side effects and interactions 3, 5.

Safety and Side Effects

• Phentermine can be associated with side effects, such as gastrointestinal discomfort, and potential dependency 5.
• It is crucial to weigh the benefits and risks of phentermine and other weight loss medications, considering individual factors and health status 3, 5.
• Regular monitoring and follow-up are essential to ensure safe and effective use of these medications 3, 7.