Which Selective Serotonin Reuptake Inhibitors (SSRIs) are given for Premenstrual Dysphoric Disorder (PMDD)?

From the Research

Selective Serotonin Reuptake Inhibitors (SSRIs) for Premenstrual Dysphoric Disorder (PMDD)

The following SSRIs are given for PMDD:

• Sertraline 50-150 mg/d 1
• Fluoxetine 10-20 mg/d 1
• Escitalopram 10-20 mg/d 1
• Paroxetine 12.5-25 mg/d 1
• Citalopram 20-40 mg/day 2

Administration of SSRIs

SSRIs can be administered:

• Continuously throughout the entire cycle 3, 4, 5
• Intermittently from ovulation to the onset of menstruation (luteal phase) 2, 3, 4

Efficacy of SSRIs

SSRIs have been shown to be effective in reducing premenstrual symptoms in women with PMDD:

• Fluoxetine, sertraline, paroxetine, and citalopram have reported positive efficacy 4
• SSRIs probably reduce overall self-rated premenstrual symptoms in women with PMS and PMDD 5
• Continuous administration of SSRIs is probably more effective than luteal phase administration 5

Adverse Effects of SSRIs

The adverse effects associated with SSRIs include:

• Nausea 5
• Insomnia 5
• Sexual dysfunction or decreased libido 5
• Fatigue or sedation 5
• Dizziness or vertigo 5
• Tremor 5
• Somnolence and decreased concentration 5
• Sweating 5
• Dry mouth 5
• Asthenia or decreased energy 5
• Diarrhoea 5
• Constipation 5