Differential Diagnosis for Clotting Disorder with Bilateral Iliac Vein Thrombosis
- Single most likely diagnosis:
- Deep Vein Thrombosis (DVT) with underlying condition: This is the most likely diagnosis due to the presentation of clotting in bilateral iliac veins, which is a common site for DVT. The underlying condition could be a hypercoagulable state, immobilization, or other risk factors for DVT.
- Other Likely diagnoses:
- Factor V Leiden thrombophilia: A genetic disorder that increases the risk of developing blood clots due to a mutation in the factor V gene, making it resistant to inactivation by protein C.
- Antithrombin III deficiency: A condition characterized by a deficiency of antithrombin III, a protein that helps regulate blood clotting, leading to an increased risk of thrombosis.
- Protein C or S deficiency: Deficiencies in these proteins, which are involved in the regulation of blood clotting, can increase the risk of developing blood clots.
- Do Not Miss diagnoses:
- Pulmonary embolism: Although not directly related to iliac vein thrombosis, it's a potential complication of DVT that can be life-threatening if missed.
- Cancer-associated thrombosis: Certain types of cancer can increase the risk of blood clots, including DVT, due to a hypercoagulable state.
- Antiphospholipid syndrome: An autoimmune disorder that can cause blood clots, including DVT, and is associated with a high risk of recurrent thrombosis.
- Rare diagnoses:
- Behçet's disease: A rare autoimmune disorder that can cause blood clots, including DVT, due to inflammation of blood vessels.
- Paget-Schroetter syndrome: A rare condition characterized by thrombosis of the upper extremity veins, but can also affect the lower extremities, including the iliac veins.
- May-Thurner syndrome: A rare condition caused by compression of the left common iliac vein by the right common iliac artery, leading to increased risk of DVT in the left leg.